Title:
ANTIHYPERTENSIVE PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2012/141385
Kind Code:
A1
Abstract:
The present invention provides an antihypertensive pharmaceutical composition containing Fimasartan, a pharmaceutically acceptable salt thereof, a solvate thereof or a hydrate thereof as an angiotensin II receptor blocker; and Amlodipine, an isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof or a hydrate thereof as a calcium channel blocker.
Inventors:
KIM SEUNG HO (KR)
KIM JI HAN (KR)
YU KYUNG SANG (KR)
JANG IN JIN (KR)
SHIN SANG GOO (KR)
YOON SEO HYUN (KR)
CHO JOO YOUN (KR)
KIM TAE EUN (KR)
YI SO JEONG (KR)
PAIK SOO HEUI (KR)
CHI YONG HA (KR)
LEE JOO HAN (KR)
NAM KYUNG WAN (KR)
KIM JE HAK (KR)
KIM JI HAN (KR)
YU KYUNG SANG (KR)
JANG IN JIN (KR)
SHIN SANG GOO (KR)
YOON SEO HYUN (KR)
CHO JOO YOUN (KR)
KIM TAE EUN (KR)
YI SO JEONG (KR)
PAIK SOO HEUI (KR)
CHI YONG HA (KR)
LEE JOO HAN (KR)
NAM KYUNG WAN (KR)
KIM JE HAK (KR)
Application Number:
PCT/KR2011/005754
Publication Date:
October 18, 2012
Filing Date:
August 08, 2011
Export Citation:
Assignee:
BORYUNG PHARM (KR)
International Classes:
A61K31/41; A61K31/44; A61K31/505; A61P9/12
Other References:
YI, SO JEONG. ET AL.: "Pharmacokinetic interaction of Fimasartan, a new angiotensin II receptor antagonist, with Amlodipine in healthy volunteers.", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY., vol. 57, no. ISSUE, 9 March 2011 (2011-03-09), pages 682 - 689
FERRI, C. ET AL.: "Role of combination therapy in the treatment of hypertensio n: focus on valsartan plus amlodipine.", ADVANCES IN THERAPY., vol. 25, no. 4, 2008, pages 300 - 320
STANGIER, J.: "Pharmacokinetics of repeated oral doses of amlodipine and amlod ipine plus telmisartan in healthy volunteers.", THE JOURNAL OF CLINICAL PHARMACOLOGY., vol. 40, no. 12, 2000, pages 1347 - 1354
CHRYSANT, STEVEN G.: "The Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure: COACH, a Randomized, Double-Blin d, Placebo-Controlled, 8-Week Factorial Efficacy and Safety Study.", CLINICAL THERAPEUTICS., vol. 30, no. 4, 2008, pages 587 - 604, XP022671119, DOI: doi:10.1016/j.clinthera.2008.04.002
FERRI, C. ET AL.: "Role of combination therapy in the treatment of hypertensio n: focus on valsartan plus amlodipine.", ADVANCES IN THERAPY., vol. 25, no. 4, 2008, pages 300 - 320
STANGIER, J.: "Pharmacokinetics of repeated oral doses of amlodipine and amlod ipine plus telmisartan in healthy volunteers.", THE JOURNAL OF CLINICAL PHARMACOLOGY., vol. 40, no. 12, 2000, pages 1347 - 1354
CHRYSANT, STEVEN G.: "The Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure: COACH, a Randomized, Double-Blin d, Placebo-Controlled, 8-Week Factorial Efficacy and Safety Study.", CLINICAL THERAPEUTICS., vol. 30, no. 4, 2008, pages 587 - 604, XP022671119, DOI: doi:10.1016/j.clinthera.2008.04.002
Attorney, Agent or Firm:
AHN, So Young (10th Fl. Shinseung Bldg., 1676-1, Seocho-dong, Seocho-gu, Seoul 137-881, KR)
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Claims: