Title:
ANTIINFLAMMATORY AGENT COMPRISING DIFFERENTIATION-INDUCING FACTOR OR ANALOG THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/046200
Kind Code:
A1
Abstract:
Provided is a composition to be used as drugs, foods or cosmetics efficacious for treating inflammation and/or tumor, which has a novel mechanism of action and shows fewer side effects. The composition comprises a clinically effective amount of a compound belonging to the DIF family or a salt thereof that is acceptable for using in drugs, foods or cosmetics, together with an excipient or carrier that is acceptable for using in drugs, foods or cosmetics.
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Inventors:
TAKAHASHI FUMI (JP)
SASAGURI TOSHIYUKI (JP)
SASAGURI TOSHIYUKI (JP)
Application Number:
PCT/JP2010/068157
Publication Date:
April 21, 2011
Filing Date:
October 15, 2010
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
TAKAHASHI FUMI (JP)
SASAGURI TOSHIYUKI (JP)
TAKAHASHI FUMI (JP)
SASAGURI TOSHIYUKI (JP)
International Classes:
A61K31/121; A23L1/30; A61K8/35; A61K8/368; A61K31/192; A61P9/10; A61P11/06; A61P29/00; A61P35/00; A61P37/02; A61P43/00; A61Q5/02; A61Q5/06; A61Q19/00; A61Q19/10
Foreign References:
| JP2006340615A | 2006-12-21 |
Other References:
YUZURU KUBOHARA: "Saibosei Nenkin Yurai no Yakuri Kassei Busshitsu DIF-1 ga Shimesu Koshuyo Sayo to To Taisha Sokushin Sayo", CELL TECHNOLOGY, vol. 26, no. 9, 2007, pages 1052 - 1053
YUZURU KUBOHARA: "Pharmacological activities of the Dictyostelium differentiation-inducing factor-1 (DIF-1) : Cellular slime molds are fascinating lower eukaryotes!", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 79, no. 2, 2007, pages 148 - 151
LIGHTOWLER, J.E. ET AL.: "On the anti- inflammatory activity of some substituted phenolic compounds", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 22, no. 2, 1964, pages 221 - 227
CECHINEL-FILHO, V. ET AL.: "Synthesis of xanthoxyline derivatives with antinociceptive and antioedematogenic activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 10, 1996, pages 833 - 839, XP004070198, DOI: doi:10.1016/0223-5234(96)83978-X
TAKAHASHI, F. ET AL.: "Differentiation-inducing factors suppressed the expression of mPGES-1 induced by LPS in THP-1 cells", J PHARMACOL SCI, vol. 112, no. SUPPLE, 15 February 2010 (2010-02-15), pages 213P
YUZURU KUBOHARA: "Pharmacological activities of the Dictyostelium differentiation-inducing factor-1 (DIF-1) : Cellular slime molds are fascinating lower eukaryotes!", JOURNAL OF JAPANESE BIOCHEMICAL SOCIETY, vol. 79, no. 2, 2007, pages 148 - 151
LIGHTOWLER, J.E. ET AL.: "On the anti- inflammatory activity of some substituted phenolic compounds", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 22, no. 2, 1964, pages 221 - 227
CECHINEL-FILHO, V. ET AL.: "Synthesis of xanthoxyline derivatives with antinociceptive and antioedematogenic activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 10, 1996, pages 833 - 839, XP004070198, DOI: doi:10.1016/0223-5234(96)83978-X
TAKAHASHI, F. ET AL.: "Differentiation-inducing factors suppressed the expression of mPGES-1 induced by LPS in THP-1 cells", J PHARMACOL SCI, vol. 112, no. SUPPLE, 15 February 2010 (2010-02-15), pages 213P
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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