Title:
ANTIMALARIAL DRUG
Document Type and Number:
WIPO Patent Application WO/2021/200934
Kind Code:
A1
Abstract:
The present invention provides a compound indicated by formula (I) or a salt thereof that is useful for the prevention or treatment of malaria (in the formula, each of the symbols is as defined in the specification).
More Like This:
Inventors:
MIZUTA SATOSHI (JP)
HIRAYAMA KENJI (JP)
MIZUKAMI SHUSAKU (JP)
MOSADDEQUE FARHANA (JP)
HUY NGUYEN TIEN (JP)
HIRAYAMA KENJI (JP)
MIZUKAMI SHUSAKU (JP)
MOSADDEQUE FARHANA (JP)
HUY NGUYEN TIEN (JP)
Application Number:
PCT/JP2021/013516
Publication Date:
October 07, 2021
Filing Date:
March 30, 2021
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
C07D401/12; A61K31/4184; A61K31/427; A61K31/436; A61K31/4375; A61K31/4439; A61K31/4709; A61P33/06; C07D403/12; C07D409/12; C07D417/12; C07D471/04; C07D491/056
Foreign References:
JP2011524365A | 2011-09-01 | |||
US20180105500A1 | 2018-04-19 | |||
US20170042905A1 | 2017-02-16 | |||
JP2019504009A | 2019-02-14 | |||
US20120329747A1 | 2012-12-27 |
Other References:
WICHT KATHRYN J., COMBRINCK JILL M., SMITH PETER J., HUNTER ROGER, EGAN TIMOTHY J.: "Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 59, no. 13, 14 July 2016 (2016-07-14), US , pages 6512 - 6530, XP055924596, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00719
ODAME FELIX, BETZ RICHARD, HOSTEN ERIC C., KRAUSE JASON, ISAACS MICHELLE, HOPPE HEINRICH C., KHANYE SETSHABA D., SAYED YASIEN, FRO: "A New Synthetic Method for Tetraazatricyclic Derivatives and Evaluation of Their Biological Properties", CHEMISTRYSELECT, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 3, no. 48, 28 December 2018 (2018-12-28), DE , pages 13613 - 13618, XP055924660, ISSN: 2365-6549, DOI: 10.1002/slct.201802930
CHAMPBELL, C. 0. ET AL.: "In silica Characterization of an Atypical MAPK Phosphatase of Plasmodium falciparum as a Suitable Target for Drug Discovery", CHEM. BIOL. DRUG. DES., vol. 84, 2014, pages 158 - 168, XP055373623, DOI: 10.1111/cbdd.12315
SUJATHA KODAM, OMMI NAIDU BABU, MUDIRAJ ANWITA, BABU PHANITHI PRAKASH, VEDULA RAJESWAR RAO: "Synthesis of thiazolyl hydrazonothiazolamines and 1,3,4‐thiadiazinyl hydrazonothiazolamines as a class of antimalarial agents", ARCHIV DER PHARMAZIE, WILEY VERLAG, WEINHEIM, vol. 352, no. 12, 1 December 2019 (2019-12-01), Weinheim , XP055924672, ISSN: 0365-6233, DOI: 10.1002/ardp.201900079
SOUVIK SARKAR, ASIM A. SIDDIQUI, SHUBHRA J. SAHA, RUDRANIL DE, SOMNATH MAZUMDER, CHINMOY BANERJEE, MOHD S. IQBAL, SHILADITYA NAG, : "ABSTRACT", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 60, no. 7, 1 July 2016 (2016-07-01), US , pages 4217 - 4228, XP055522624, ISSN: 0066-4804, DOI: 10.1128/AAC.01575-15
GEMMA SANDRA; GIOVANI SIMONE; BRINDISI MARGHERITA; TRIPALDI PIERANGELA; BROGI SIMONE; SAVINI LUISA; FIORINI ISABELLA; NOVELLINO ET: "Quinolylhydrazones as novel inhibitors ofPlasmodium falciparumserine protease PfSUB1", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 16, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 5317 - 5321, XP028932824, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2012.06.023
SUBRAMANIAN GOWTHAM, BABU RAJEEV C.P., MOHAN CHAKRABHAVI DHANANJAYA, SINHA AMEYA, CHU TRANG T.T., ANUSHA SEBASTIAN, XIMEI HUANG, F: "Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 14, 1 July 2016 (2016-07-01), AMSTERDAM, NL , pages 3300 - 3306, XP055924676, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.05.049
SHI HAIBIN, TICE COLIN M., EMERT-SEDLAK LORI, CHEN LI, LI WING FAI, CARLSEN MARIANNE, WROBEL JAY E., REITZ ALLEN B., SMITHGALL THO: "Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation", ACS INFECTIOUS DISEASES, AMERICAN CHEMICAL SOCIETY, US, vol. 6, no. 2, 14 February 2020 (2020-02-14), US , pages 302 - 312, XP055924686, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.9b00382
ODAME FELIX, BETZ RICHARD, HOSTEN ERIC C., KRAUSE JASON, ISAACS MICHELLE, HOPPE HEINRICH C., KHANYE SETSHABA D., SAYED YASIEN, FRO: "A New Synthetic Method for Tetraazatricyclic Derivatives and Evaluation of Their Biological Properties", CHEMISTRYSELECT, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 3, no. 48, 28 December 2018 (2018-12-28), DE , pages 13613 - 13618, XP055924660, ISSN: 2365-6549, DOI: 10.1002/slct.201802930
CHAMPBELL, C. 0. ET AL.: "In silica Characterization of an Atypical MAPK Phosphatase of Plasmodium falciparum as a Suitable Target for Drug Discovery", CHEM. BIOL. DRUG. DES., vol. 84, 2014, pages 158 - 168, XP055373623, DOI: 10.1111/cbdd.12315
SUJATHA KODAM, OMMI NAIDU BABU, MUDIRAJ ANWITA, BABU PHANITHI PRAKASH, VEDULA RAJESWAR RAO: "Synthesis of thiazolyl hydrazonothiazolamines and 1,3,4‐thiadiazinyl hydrazonothiazolamines as a class of antimalarial agents", ARCHIV DER PHARMAZIE, WILEY VERLAG, WEINHEIM, vol. 352, no. 12, 1 December 2019 (2019-12-01), Weinheim , XP055924672, ISSN: 0365-6233, DOI: 10.1002/ardp.201900079
SOUVIK SARKAR, ASIM A. SIDDIQUI, SHUBHRA J. SAHA, RUDRANIL DE, SOMNATH MAZUMDER, CHINMOY BANERJEE, MOHD S. IQBAL, SHILADITYA NAG, : "ABSTRACT", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 60, no. 7, 1 July 2016 (2016-07-01), US , pages 4217 - 4228, XP055522624, ISSN: 0066-4804, DOI: 10.1128/AAC.01575-15
GEMMA SANDRA; GIOVANI SIMONE; BRINDISI MARGHERITA; TRIPALDI PIERANGELA; BROGI SIMONE; SAVINI LUISA; FIORINI ISABELLA; NOVELLINO ET: "Quinolylhydrazones as novel inhibitors ofPlasmodium falciparumserine protease PfSUB1", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 22, no. 16, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 5317 - 5321, XP028932824, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2012.06.023
SUBRAMANIAN GOWTHAM, BABU RAJEEV C.P., MOHAN CHAKRABHAVI DHANANJAYA, SINHA AMEYA, CHU TRANG T.T., ANUSHA SEBASTIAN, XIMEI HUANG, F: "Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 14, 1 July 2016 (2016-07-01), AMSTERDAM, NL , pages 3300 - 3306, XP055924676, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2016.05.049
SHI HAIBIN, TICE COLIN M., EMERT-SEDLAK LORI, CHEN LI, LI WING FAI, CARLSEN MARIANNE, WROBEL JAY E., REITZ ALLEN B., SMITHGALL THO: "Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation", ACS INFECTIOUS DISEASES, AMERICAN CHEMICAL SOCIETY, US, vol. 6, no. 2, 14 February 2020 (2020-02-14), US , pages 302 - 312, XP055924686, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.9b00382
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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