Title:
ANTIMICROBIAL ACTIVITY ENHANCING AGENT
Document Type and Number:
WIPO Patent Application WO/2012/015037
Kind Code:
A1
Abstract:
An antimicrobial activity enhancing agent for lactoferrin or lactoferrin hyrdolysate with milk-derived protein which has the properties below as the active ingredient, and a method for producing the antimicrobial activity enhancing agent characterized by including: (a) a step of contacting raw milk to a cation exchange resin to adsorb the protein in the milk into the cation exchange resin; (b) a step of subjecting the cation exchange resin to a cleaning treatment after the adsorption treatment and passing the resin through a dissolution medium to elute a protein fraction with an isoelectric point of 9.0 to 11.0; and (c) a step of membrane filtering the eluted protein fraction using an ultrafiltration membrane having a molecular weight cut off of 30 kDa to prepare a milk-derived protein having the following properties:
(A) an effect of enhancing antimicrobial activity of lactoferrin or lactoferrin hyrdolysate,
(B) a molecular weight of 30 kDa or less,
and
(C) an isoelectric point of 9.0 to 11.0.
Inventors:
MURATA, Mai (Food Science & Technology Institute, 1-83, Higashihara 5-chome, Zama-sh, Kanagawa 83, 〒2528583, JP)
村田 麻衣 (〒83 神奈川県座間市東原五丁目１番８３号 森永乳業株式会社 食品基盤研究所内 Kanagawa, 〒2528583, JP)
WAKABAYASHI, Hiroyuki (Food Science & Technology Institute, 1-83, Higashihara 5-chome, Zama-sh, Kanagawa 83, 〒2528583, JP)
村田 麻衣 (〒83 神奈川県座間市東原五丁目１番８３号 森永乳業株式会社 食品基盤研究所内 Kanagawa, 〒2528583, JP)
WAKABAYASHI, Hiroyuki (Food Science & Technology Institute, 1-83, Higashihara 5-chome, Zama-sh, Kanagawa 83, 〒2528583, JP)
Application Number:
JP2011/067488
Publication Date:
February 02, 2012
Filing Date:
July 29, 2011
Export Citation:
Assignee:
MORINAGA MILK INDUSTRY CO., LTD. (33-1, Shiba 5-chome Minato-k, Tokyo 84, 〒1088384, JP)
森永乳業株式会社 (〒84 東京都港区芝五丁目３３番１号 Tokyo, 〒1088384, JP)
MURATA, Mai (Food Science & Technology Institute, 1-83, Higashihara 5-chome, Zama-sh, Kanagawa 83, 〒2528583, JP)
村田 麻衣 (〒83 神奈川県座間市東原五丁目１番８３号 森永乳業株式会社 食品基盤研究所内 Kanagawa, 〒2528583, JP)
森永乳業株式会社 (〒84 東京都港区芝五丁目３３番１号 Tokyo, 〒1088384, JP)
MURATA, Mai (Food Science & Technology Institute, 1-83, Higashihara 5-chome, Zama-sh, Kanagawa 83, 〒2528583, JP)
村田 麻衣 (〒83 神奈川県座間市東原五丁目１番８３号 森永乳業株式会社 食品基盤研究所内 Kanagawa, 〒2528583, JP)
International Classes:
A61K38/00; A23K1/16; A23L1/305; A23L2/52; A61K38/22; A61P31/04; A61P43/00
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (Acropolis 21 Building 6th floor, 4-10 Higashi Nihonbashi 3-chome, Chuo-k, Tokyo 04, 〒1030004, JP)
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Claims:
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