Title:
ANTIMICROBIAL ACTIVITY ENHANCING AGENT
Document Type and Number:
WIPO Patent Application WO/2013/018169
Kind Code:
A1
Abstract:
A lactoferrin or lactoferrin hydrolyzate antimicrobial activity enhancing agent in which the active ingredient is ribonuclease-4, as well as a method for producing a lactoferrin or lactoferrin hydrolyzate antimicrobial activity enhancing agent, the method being characterized in comprising: a step (a) for bringing a crude dairy material into contact with a cation-exchange resin to adsorb protein in the crude dairy material to the cation-exchange resin; a step (b) for washing the cation-exchange resin after the adsorption, and passing the same through an elution solvent to elute a fraction having an isoelectric point of 8.0 to 10.0; and a step (c) for subjecting the eluted protein fraction to gel filtration using a gel filter carrier, to recover a fraction having a molecular weight of 30 kDa or lower.
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Inventors:
MURATA MAI (JP)
WAKABAYASHI HIROYUKI (JP)
YAMAUCHI KOJI (JP)
WAKABAYASHI HIROYUKI (JP)
YAMAUCHI KOJI (JP)
Application Number:
PCT/JP2011/067491
Publication Date:
February 07, 2013
Filing Date:
July 29, 2011
Export Citation:
Assignee:
MORINAGA MILK INDUSTRY CO LTD (JP)
MURATA MAI (JP)
WAKABAYASHI HIROYUKI (JP)
YAMAUCHI KOJI (JP)
MURATA MAI (JP)
WAKABAYASHI HIROYUKI (JP)
YAMAUCHI KOJI (JP)
International Classes:
A61K38/00; A01N63/50; A23J3/08; A23L2/52; A23L2/66; A23L2/74; A23L2/78; A23L29/00; A23L33/17; A23L33/18; A61K38/43; A61K38/46; A61P31/04; A61P31/18; A61P43/00; C07K14/79; C12N9/22
Foreign References:
| JP2006006257A | 2006-01-12 | |||
| JP2006187300A | 2006-07-20 | |||
| JPH0748274A | 1995-02-21 | |||
| JPH06312922A | 1994-11-08 | |||
| JPH11292789A | 1999-10-26 | |||
| JPH05255109A | 1993-10-05 | |||
| JPH05320067A | 1993-12-03 | |||
| JPH06199698A | 1994-07-19 | |||
| JPH09124504A | 1997-05-13 | |||
| JPH1192375A | 1999-04-06 | |||
| JPH03171736A | 1991-07-25 |
Other References:
HARRIS P. ET AL.: "Characterisation of the anti-microbial activity of bovine milk ribonuclease4 and ribonuclease5 (angiogenin)", INTERNATIONAL DAIRY JOURNAL, vol. 20, no. 6, June 2010 (2010-06-01), pages 400 - 407, XP055075177
WELSH, J.K. ET AL., JOURNAL OF PEDIATRICS, vol. 94, 1979, pages 1 - 9
NONNECKE, B.J. ET AL., JOURNAL OF DAIRY SCIENCE, vol. 67, 1984, pages 606 - 613
BELLAMY, W. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1121, 1992, pages 130 - 136
BELLAMY, W. ET AL., JOURNAL OF APPLIED BACTERIOLOGY, vol. 73, 1992, pages 472 - 479
See also references of EP 2737903A4
WELSH, J.K. ET AL., JOURNAL OF PEDIATRICS, vol. 94, 1979, pages 1 - 9
NONNECKE, B.J. ET AL., JOURNAL OF DAIRY SCIENCE, vol. 67, 1984, pages 606 - 613
BELLAMY, W. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1121, 1992, pages 130 - 136
BELLAMY, W. ET AL., JOURNAL OF APPLIED BACTERIOLOGY, vol. 73, 1992, pages 472 - 479
See also references of EP 2737903A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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