Title:
ANTIMICROBIAL COMPOSITION CONTAINING CYCLIC DIPEPTIDE COMPOUND ISOLATED FROM FERMENTED LIQUID OF LACTOBACILLUS PARAPLANTARUM KNUC25 STRAIN, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/110992
Kind Code:
A1
Abstract:
The present invention relates to: a composition containing, as an active ingredient, a cyclic dipeptide compound, which is isolated from a fermented liquid of a Lactobacillus paraplantarum KNUC25 strain, and having antimicrobial activity; a preparation method for the compound; and a use thereof. The cyclic dipeptide compound according to the present invention is isolated from a fermented liquid of a Lactobacillus paraplantarum strain and exhibits excellent antimicrobial activity on pathogenic bacteria, including gram-negative bacteria and gram-positive bacteria, and on pathogenic fungi, thereby being usable as an antimicrobial additive composition during the preparation of foods, drugs, cosmetic products, and the like. In addition, according to the preparation method of the present invention, the cyclic dipeptide is stably isolated from the strain and purified, and thus is expected to be more stable and have higher industrial utilization value than compounds present in microorganisms themselves.
Inventors:
GHIM SA-YOUL (KR)
KIM MARIE (KR)
HWANG YE-JI (KR)
KIM MARIE (KR)
HWANG YE-JI (KR)
Application Number:
PCT/KR2017/014704
Publication Date:
June 21, 2018
Filing Date:
December 14, 2017
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
A01N43/60; A01N43/90; A23L3/3526; A23L29/00; A61K8/49; A61K31/496; A61Q19/00
Foreign References:
| KR20120007995A | 2012-01-25 |
Other References:
KUMAR, SASIDHARAN NISHANTH ET AL.: "Biocontrol of Aspergillus Species on Peanut Kernels by Antifungal Diketopiperazine Producing Bacillus Cereus Associated with Entomopathogenic Nematode", PLOS ONE, vol. 9, no. 8, pages e106041, XP055517216
SAJELI BEGUM, AHIL ET AL.: "Isolation and Characterization of Antimicrobial Cyclic Dipeptides from Pseudomonas Fluorescens and Their Efficacy on Sorghum Grain Mold Fungi", CHEMISTRY & BIODIVERSITY, vol. 11, 2014, pages 92 - 100, XP055517223
STROM, KATRIN ET AL.: "Lactobacillus Plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo (L-Phe-L-Pro) and Cyclo (L-Phe-trans-4-OH-L-Pro) and 3-phenyllactic Acid", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 68, no. 9, September 2002 (2002-09-01), pages 4322 - 4327, XP008064284
VALAN ARASU, M. ET AL.: "Isolation and Characterization of Antifungal Compound from Lactobacillus Plantation KCC-10 from Forage Silage with Potential Beneficial Properties", JOURNAL OF APPLIED MICROBIOLOGY, vol. 115, no. 5, 2013, pages 1172 - 1185, XP055517228
KIM, MARIE ET AL.: "Abstrac (A-26)Identifïcation of Bioactive Compounds from Fermented Culture Medium of Lactobacillus Paraplantarum KNUC25 Isolated from Kimchi", THE KOREAN SOCIETY FOR MICROBIOLOGY & BIOTECHNOLOGY , 43RD ANNUAL MEETING & INTERNATIONAL SYMPOSIUM, 22 June 2016 (2016-06-22), Daejeon, Korea, XP055517285
SAJELI BEGUM, AHIL ET AL.: "Isolation and Characterization of Antimicrobial Cyclic Dipeptides from Pseudomonas Fluorescens and Their Efficacy on Sorghum Grain Mold Fungi", CHEMISTRY & BIODIVERSITY, vol. 11, 2014, pages 92 - 100, XP055517223
STROM, KATRIN ET AL.: "Lactobacillus Plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo (L-Phe-L-Pro) and Cyclo (L-Phe-trans-4-OH-L-Pro) and 3-phenyllactic Acid", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 68, no. 9, September 2002 (2002-09-01), pages 4322 - 4327, XP008064284
VALAN ARASU, M. ET AL.: "Isolation and Characterization of Antifungal Compound from Lactobacillus Plantation KCC-10 from Forage Silage with Potential Beneficial Properties", JOURNAL OF APPLIED MICROBIOLOGY, vol. 115, no. 5, 2013, pages 1172 - 1185, XP055517228
KIM, MARIE ET AL.: "Abstrac (A-26)Identifïcation of Bioactive Compounds from Fermented Culture Medium of Lactobacillus Paraplantarum KNUC25 Isolated from Kimchi", THE KOREAN SOCIETY FOR MICROBIOLOGY & BIOTECHNOLOGY , 43RD ANNUAL MEETING & INTERNATIONAL SYMPOSIUM, 22 June 2016 (2016-06-22), Daejeon, Korea, XP055517285
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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