Title:
ANTIMICROBIAL COMPOUND HAVING ANTI-DRUG RESISTANCE
Document Type and Number:
WIPO Patent Application WO/2023/088308
Kind Code:
A1
Abstract:
A class of steroid derivatives, and a preparation method therefor, a pharmaceutical composition and the use thereof. The steroid derivative is represented by formula (I 0), and also comprises a hydrate, a solvate, an isotope derivative, a diastereomer or a pharmaceutically acceptable salt of the compound. The compound exhibits a good antimicrobial activity and is effective against various drug-resistant microbes. The antimicrobial compound exhibits a very good distribution in skin tissue and a very low systemic exposure when administered to skin.
Inventors:
WANG LU (CN)
MENG YUELEI (CN)
MENG YUELEI (CN)
Application Number:
PCT/CN2022/132275
Publication Date:
May 25, 2023
Filing Date:
November 16, 2022
Export Citation:
Assignee:
SHIJIAZHUANG DISCOVERY MEDICINE TECH CO LTD (CN)
International Classes:
A61K31/573; C07J5/00; A61P5/28; A61P31/04; A61P31/10; A61P35/00; C07J9/00
Foreign References:
| CN107001406A | 2017-08-01 | |||
| US3152154A | 1964-10-06 | |||
| CN1105368A | 1995-07-19 | |||
| US4920216A | 1990-04-24 | |||
| US5362721A | 1994-11-08 | |||
| CN1541220A | 2004-10-27 | |||
| CN112512528A | 2021-03-16 | |||
| CN110099688A | 2019-08-06 |
Other References:
FERRABOSCHI, PATRIZIA ET AL.: "Lipase-catalyzed preparation of corticosteroid 17a-esters endowed with antiandrogenic activity", TETRAHEDRON LETTERS, vol. 49, 23 May 2008 (2008-05-23), pages 4610 - 4612, XP022757401, DOI: 10.1016/j.tetlet.2008.05.086
ANNEN, KLAUS ET AL.: "17-Pivalate in der Pregnanreihe", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 4, 31 December 1983 (1983-12-31), pages 705 - 711, XP001119196
ANNEN, KLAUS ET AL.: "17-Pivalate in der Pregnanreihe", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 4, 31 December 1983 (1983-12-31), pages 705 - 711, XP001119196
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