Title:
ANTIMICROBIAL COMPOUNDS AND NANOSTRUCTURES
Document Type and Number:
WIPO Patent Application WO/2018/232005
Kind Code:
A3
Abstract:
The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.
Inventors:
MONTEIRO MICHAEL (AU)
ARMSTRONG JASON W (US)
ARMSTRONG JASON W (US)
Application Number:
PCT/US2018/037360
Publication Date:
June 06, 2019
Filing Date:
June 13, 2018
Export Citation:
Assignee:
BOEING CO (US)
International Classes:
A61K31/787; A61K31/795; C08F120/34; C08F120/56
Other References:
HOLDSWORTH, CI ET AL.: "RAFT-Mediated Emulsion polymerization of Styrene with a Thermoresponsive MacroCTA", POLYMER, 2016, pages 1 - 27, XP029824719
VOGT, ANDREW P: "Macromolecular Design Via Combinations of Controlled Radical Polymerization Techniques and Click Chemistry", DOCTORAL THESIS, 2009, pages 1 - 167, XP009518540
KOUMBA, AMB: "Design, Synthesis and Characterisation of Amphiphilic Symmetrical Triblock Copolymers by the RAFT Process: Their Self-Organisation in Dilute and Concentrated Aqueous Solutions", DOCTORAL THESIS, 2009, pages 1 - 79, XP055593767
ZHANG, W ET AL.: "One-Pot Synthesis of Poly(methacrylic acid-co-poly(ethylene oxide) methyl ether methacrylate)-b-polystyrene Amphiphilic Block Copolymers and Their Self-Assemblies in Water via RAFT-Mediated Radical Emulsion Polymerization", A KINETIC STUDY, MACROMOLECULES, vol. 44, no. 19, 2011, pages 7584 - 7593, XP055161135, DOI: 10.1021/ma201515n
MA, J ET AL.: "Preparation of Thermo-Responsive and Cross-Linked Fluorinated Nanoparticles via RAFT-Mediated Aqueous Polymerization in Nanoreactors", MOLECULES, vol. 22, no. 152, 25 January 2017 (2017-01-25), pages 1 - 13, XP055593779
ARMENTANO ET AL.: "THE INTERACTION OF BACTERIA WITH ENGINEERED NANOSTRUCTURED POLYMERIC MATERIALS: A REVIEW", THE SCIENTIFIC WORLD JOURNAL, vol. 2014, 410423, 15 June 2014 (2014-06-15), pages 1 - 18, XP002793267
MINGHONG ZHOU ET AL.: "SYNTHESIS OF MAGNETIC MICROPOROUS ORGANIC NANOTUBE NETWORDS FOR ADSORPTION APPLICATION", RSC ADVANCES, vol. 6, 2016, pages 87745 - 87752, XP002793268
VOGT, ANDREW P: "Macromolecular Design Via Combinations of Controlled Radical Polymerization Techniques and Click Chemistry", DOCTORAL THESIS, 2009, pages 1 - 167, XP009518540
KOUMBA, AMB: "Design, Synthesis and Characterisation of Amphiphilic Symmetrical Triblock Copolymers by the RAFT Process: Their Self-Organisation in Dilute and Concentrated Aqueous Solutions", DOCTORAL THESIS, 2009, pages 1 - 79, XP055593767
ZHANG, W ET AL.: "One-Pot Synthesis of Poly(methacrylic acid-co-poly(ethylene oxide) methyl ether methacrylate)-b-polystyrene Amphiphilic Block Copolymers and Their Self-Assemblies in Water via RAFT-Mediated Radical Emulsion Polymerization", A KINETIC STUDY, MACROMOLECULES, vol. 44, no. 19, 2011, pages 7584 - 7593, XP055161135, DOI: 10.1021/ma201515n
MA, J ET AL.: "Preparation of Thermo-Responsive and Cross-Linked Fluorinated Nanoparticles via RAFT-Mediated Aqueous Polymerization in Nanoreactors", MOLECULES, vol. 22, no. 152, 25 January 2017 (2017-01-25), pages 1 - 13, XP055593779
ARMENTANO ET AL.: "THE INTERACTION OF BACTERIA WITH ENGINEERED NANOSTRUCTURED POLYMERIC MATERIALS: A REVIEW", THE SCIENTIFIC WORLD JOURNAL, vol. 2014, 410423, 15 June 2014 (2014-06-15), pages 1 - 18, XP002793267
MINGHONG ZHOU ET AL.: "SYNTHESIS OF MAGNETIC MICROPOROUS ORGANIC NANOTUBE NETWORDS FOR ADSORPTION APPLICATION", RSC ADVANCES, vol. 6, 2016, pages 87745 - 87752, XP002793268
Attorney, Agent or Firm:
PATTERSON, B. Todd (US)
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