Title:
ANTIMICROBIAL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1999010321
Kind Code:
A3
Abstract:
This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R-SOn-Z-CO-Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from -CH2-, -O-, and -NH-, two of these radicals coupled together, or -CH2=CH2-; Y is -NH2, O-CH2-C6H5, -CO-CO-O-CH3, or O-CH3; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize alpha -substitued, beta -hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as Mycobacterium tuberculosis, drug-resistant M. tuberculosis, M. avium intracellulare, and M. leprae.
Inventors:
TOWNSEND CRAIG A (US)
DICK JAMES D (US)
PASTERNACK GARY R (US)
KUHAJDA FRANCIS P (US)
PARRISH NICOLE M (US)
DICK JAMES D (US)
PASTERNACK GARY R (US)
KUHAJDA FRANCIS P (US)
PARRISH NICOLE M (US)
Application Number:
PCT/US1998/017830
Publication Date:
September 30, 1999
Filing Date:
August 28, 1998
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
TOWNSEND CRAIG A (US)
DICK JAMES D (US)
PASTERNACK GARY R (US)
KUHAJDA FRANCIS P (US)
PARRISH NICOLE M (US)
TOWNSEND CRAIG A (US)
DICK JAMES D (US)
PASTERNACK GARY R (US)
KUHAJDA FRANCIS P (US)
PARRISH NICOLE M (US)
International Classes:
A61K31/04; A61K31/16; A61K31/18; A61K31/215; A61K31/22; C07B61/00; C07C311/06; C07C317/44; C40B40/04; (IPC1-7): C07C311/06; C07C317/44; A61K31/18; A61K31/22
Domestic Patent References:
| WO1995019706A1 | 1995-07-27 |
Foreign References:
| DE2630947A1 | 1977-02-03 | |||
| DE2729685A1 | 1978-01-05 | |||
| US5530113A | 1996-06-25 |
Other References:
M. MIKOLAJCZYK ET AL, TETRAHEDRON, vol. 32, no. 8, 1976, pages 969 - 973, XP002096632
C. GEORGES ET AL, J. CHEM. SOC., FARADAY TRANS. 1, vol. 84, no. 5, 1988, pages 1531 - 1542, XP002096633
M.S.F. JIE ET AL, CHEM. PHYS. LIPIDS, vol. 61, no. 2, 1992, pages 139 - 147, XP002096634
DATABASE CHEMLIST AMERICAN CHEMICAL SOCIETY; XP002096636
F.E. HARDY ET AL, J. CHEM. SOC. C, no. 17, 1969, pages 2334 - 2336, XP002096635
C. GEORGES ET AL, J. CHEM. SOC., FARADAY TRANS. 1, vol. 84, no. 5, 1988, pages 1531 - 1542, XP002096633
M.S.F. JIE ET AL, CHEM. PHYS. LIPIDS, vol. 61, no. 2, 1992, pages 139 - 147, XP002096634
DATABASE CHEMLIST AMERICAN CHEMICAL SOCIETY; XP002096636
F.E. HARDY ET AL, J. CHEM. SOC. C, no. 17, 1969, pages 2334 - 2336, XP002096635
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