Title:
ANTIMICROBIAL PEPTIDES OF THE FAMILY OF DEFENSINS, POLYNUCLEOTIDES ENCODING SAID PEPTIDES, TRANSFORMED VECTORS AND ORGANISMS CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO2002000706
Kind Code:
A3
Abstract:
The invention concerns novel antimicrobial peptides of the family of defensins, in particular antifungal, called termicines, polynucleotides encoding said peptides, vectors containing them for transforming a host organism and the method for transforming said organism. The invention also concerns transformed organisms, in particular yeast producing termicine, or plant cells and plants, the termicines produced by the transformed plats providing them with resistance to fungus-mediated diseases. The invention further concerns the use of termicines as medicine and pharmaceutical compositions containing them.
Inventors:
LAMBERTY MIREILLE (FR)
BULET PHILIPPE (FR)
LATORSE MARIE-PASCALE (FR)
HOFFMANN JULES (FR)
BULET PHILIPPE (FR)
LATORSE MARIE-PASCALE (FR)
HOFFMANN JULES (FR)
Application Number:
PCT/FR2001/002028
Publication Date:
March 21, 2002
Filing Date:
June 27, 2001
Export Citation:
Assignee:
RHOBIO (FR)
LAMBERTY MIREILLE (FR)
BULET PHILIPPE (FR)
LATORSE MARIE PASCALE (FR)
HOFFMANN JULES (FR)
LAMBERTY MIREILLE (FR)
BULET PHILIPPE (FR)
LATORSE MARIE PASCALE (FR)
HOFFMANN JULES (FR)
International Classes:
A01N37/46; A01N63/50; C07K14/435; C12N1/21; C12N15/12; C12N15/82; (IPC1-7): C12N15/12; C07K14/435; C12Q1/68; C12N15/62; A01K67/027; A01H5/00; A01N63/00
Domestic Patent References:
| WO1999053053A1 | 1999-10-21 | |||
| WO1999002717A1 | 1999-01-21 |
Other References:
REICHHART J -M ET AL: "EXPRESSION AND SECRETION IN YEAST OF ACTIVE INSECT DEFENSIN AN INDUCIBLE ANTIBACTERIAL PEPTIDE FROM THE FLESHFLY PHORMIA TERRANOVAE", INTERNATIONAL JOURNAL OF INVERTEBRATE REPRODUCTION AND DEVELOPMENT, vol. 21, no. 1, February 1992 (1992-02-01), pages 15 - 24, XP000884179, ISSN: 0168-8170
LAMBERTY M ET AL: "Insect immunity - Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect", JOURNAL OF BIOLOGICAL CHEMISTRY, (9 FEB 2001) VOL. 276, NO. 6, PP. 4085-4092., XP002162835
LAMBERTY M ET AL: "Insect immunity - Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect", JOURNAL OF BIOLOGICAL CHEMISTRY, (9 FEB 2001) VOL. 276, NO. 6, PP. 4085-4092., XP002162835
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