Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ANTIMICROBIAL PEPTIDES
Document Type and Number:
WIPO Patent Application WO/2018/109042
Kind Code:
A3
Abstract:
This disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof: Formula (I), in which n, R1, R1', R2, R3, R4, R4', and R5-R14 are defined in the specification. The compounds of formula (I) can be used to treat bacterial infection.

Inventors:
HENNINOT, Antoine (1822 Roosevelt Ave #A, San Diego, California, 92109, US)
CARNEY, Daniel William (8793 Lightwave Ave, Apt. C422San Diego, California, 92123, US)
Application Number:
EP2017/082697
Publication Date:
July 26, 2018
Filing Date:
December 13, 2017
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
FERRING B.V. (Polaris Avenue 144, 2132 JX Hoofddorp, 2132 JX, NL)
International Classes:
A61K38/12; C07K5/12; C07K7/54; C07K7/56
Domestic Patent References:
WO1999067286A21999-12-29
WO2014089053A12014-06-12
WO1999026968A11999-06-03
WO2010080819A12010-07-15
WO2017181179A12017-10-19
Foreign References:
JPS50160492A1975-12-25
CN106632604A2017-05-10
CN107266531A2017-10-20
US20140205681A12014-07-24
Other References:
HYUNJUN YANG ET AL: "Elucidation of the Teixobactin Pharmacophore", ACS CHEMICAL BIOLOGY, vol. 11, no. 7, 3 June 2016 (2016-06-03), US, pages 1823 - 1826, XP055459656, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00295
DARCY J ATKINSON ET AL: "Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 12, 7 November 2016 (2016-11-07), pages 2325 - 2342, XP055459646, DOI: 10.3762/bjoc.12.226
SHIMAA A.H. ABDEL MONAIM ET AL: "Teixobactin as a scaffold for unlimited new antimicrobial peptides: SAR study", BIOORGANIC & MEDICINAL CHEMISTRY, 1 September 2017 (2017-09-01), GB, XP055459632, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.09.040
CHRISTIAN E. SCHUMACHER ET AL: "Synthesis and biological evaluation of novel teixobactin analogues", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 15, no. 41, 1 January 2017 (2017-01-01), pages 8755 - 8760, XP055459636, ISSN: 1477-0520, DOI: 10.1039/C7OB02169K
CHUCHU GUO ET AL: "Chemistry and Biology of Teixobactin", CHEMISTRY - A EUROPEAN JOURNAL, 12 December 2017 (2017-12-12), DE, pages 1 - 18, XP055459629, ISSN: 0947-6539, DOI: 10.1002/chem.201704167
Attorney, Agent or Firm:
MUMMERY, Thomas Zack (Reddie & Grose LLP, The Whitechapel Building10 White Chapel High Street, London Greater London E1 8QS, E1 8QS, GB)
Download PDF:



 
Previous Patent: DENTAL COMPOSITION

Next Patent: RIGID SHELL