ANTINEOPLASTIC AGENT AND MANUFACTURING METHOD AND USE THEREFOR

Title:

ANTINEOPLASTIC AGENT AND MANUFACTURING METHOD AND USE THEREFOR

Document Type and Number:

WIPO Patent Application WO/2012/118068

Kind Code:

A1

Abstract:

The present invention relates to substance 3787-5-1 represented by formula (I) and pharmaceutically permissible salts thereof. Substance 3787-5-1 is useful for the prevention and treatment of a disease caused by a cell proliferative disorder, particularly a malignant tumor, because it has antineoplastic activity acting alone and also enhances the antineoplastic activity of other antineoplastic agents. This substance can be produced by culturing a microorganism of the genus Phytohabitans that is capable of producing substance 3787-5-1, particularly Phytohabitans sp. 3787-5, and collecting substance 3787-5-1 from the culture product thereof.

Inventors:

TOMODA HIROSHI (JP)
MATSUDA DAISUKE (JP)
UCHIDA RYUJI (JP)
TAKAHASHI YOKO (JP)
OMURA SATOSHI (JP)

Application Number:

PCT/JP2012/054898

Publication Date:

September 07, 2012

Filing Date:

February 28, 2012

Export Citation:

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Assignee:

SCHOOL JURIDICAL PERSON KITASATO INST (JP)
TOMODA HIROSHI (JP)
MATSUDA DAISUKE (JP)
UCHIDA RYUJI (JP)
TAKAHASHI YOKO (JP)
OMURA SATOSHI (JP)

International Classes:

C07J13/00; A61K31/568; A61P35/00; C12P15/00

Other References:

INAHASHI Y ET AL.: "Phytohabitans suttuscus gen. nov., sp. nov., an actinomycete of the family Micromonosporaceae isolated from plant roots", INT J SYST EVOL MICROBIOL., vol. 60, 2010, pages 2652 - 2658
SABRY OM ET AL.: "Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme", J NAT PROD., vol. 68, 2005, pages 1022 - 1030

Attorney, Agent or Firm:

HIROSE SHOICHI (JP)
Hirose Shoichi (JP)

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