Title:
ANTINEOPLASTIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2007059613
Kind Code:
B1
Abstract:
The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof. The method of preparation and antineoplastic activity of the said compounds are disclosed. A number of the compounds possess submicromolar IC50 and CC50 values and have a selective toxicity for colon cancers and leukemic cells. In addition, many of the compounds are able to reverse multidrug resistance.
Inventors:
DIMMOCK JONATHAN R (CA)
DAS UMASHANKAR (CA)
DAS UMASHANKAR (CA)
Application Number:
PCT/CA2006/001908
Publication Date:
July 19, 2007
Filing Date:
November 22, 2006
Export Citation:
Assignee:
UNIV SASKATCHEWAN (CA)
DIMMOCK JONATHAN R (CA)
DAS UMASHANKAR (CA)
DIMMOCK JONATHAN R (CA)
DAS UMASHANKAR (CA)
International Classes:
C07D211/44; A61K31/45; A61P35/00
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