Title:
ANTISENSE ANTIBACTERIAL COMPOUNDS AND METHODS
Document Type and Number:
WIPO Patent Application WO/2016/108930
Kind Code:
A3
Abstract:
Provided are antisense oligonucleotides targeted against bacterial genes involved in biochemical pathways and/or cellular processes, and related compositions and methods of using the oligonucleotides and compositions, alone or in combination with other antimicrobial agents, for instance, in the treatment of an infected mammalian subject. Embodiment's of the present disclosure relate, in part, to the discovery that the antisense targeting of bacterial genes involved in biochemical pathways and/or cellular processes can, inter alia, increase the antibiotic susceptibility of otherwise antibiotic-resistant pathogenic bacteria, and reduce the ability of certain pathogenic bacteria to grow.
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Inventors:
GELLER BRUCE L (US)
GREENBERG DAVID (US)
GREENBERG DAVID (US)
Application Number:
PCT/US2015/000280
Publication Date:
August 25, 2016
Filing Date:
December 23, 2015
Export Citation:
Assignee:
GELLER BRUCE L (US)
GREENBERG DAVID (US)
GREENBERG DAVID (US)
International Classes:
C07H19/16
Foreign References:
| US8314072B2 | 2012-11-20 | |||
| US20120289457A1 | 2012-11-15 | |||
| US20120296087A1 | 2012-11-22 | |||
| US20130197220A1 | 2013-08-01 |
Other References:
See also references of EP 3240794A4
Attorney, Agent or Firm:
ROGEL, Mark, E. et al. (1299 Pennsylvania Avenue NW,Suite 70, Washington DC, US)
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