Title:
ANTISENSE MODULATION OF COMPLEMENT COMPONENT C3 EXPRESSION
Document Type and Number:
WIPO Patent Application WO2003066805
Kind Code:
A3
Abstract:
Antisense compounds, compositions and methods are provided for modulating the expression of complement component C3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding complement component C3. Methods of using these compounds for modulation of complement component C3 expression and for treatment of diseases associated with expression of complement component C3 are provided.
Inventors:
GRAHAM MARK J
WATT ANDREW T
WATT ANDREW T
Application Number:
PCT/US2002/033573
Publication Date:
May 19, 2005
Filing Date:
October 17, 2002
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
International Classes:
C12N5/02; C12N15/113; C12Q1/68; A61K38/00; (IPC1-7): C12Q1/68; A01N43/04; C07H21/04; A61K31/07
Foreign References:
| US6069008A | 2000-05-30 | |||
| US5985664A | 1999-11-16 |
Other References:
BRANCH A.D.: "A good antisense molecule is hard to find", TIBS, vol. 23, 1998, pages 45 - 50, XP002947100
JEN K.Y. ET AL: "Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies", STEM CELLS, vol. 18, 2000, pages 307 - 319, XP002948605
DE BRUIJN M.H.L. ET AL: "Human complement component C3: cDNA coding sequence and derived primary structure", PROC. NATHL. ACAD. SCI., vol. 82, 1985, pages 708 - 712, XP009018561
AGRAWAL S. ET AL: "Antisense therapeutics: is it as simple as complementary base recognition", MOLECULAR MEDICINE TODAY, vol. 6, February 2000 (2000-02-01), pages 72 - 81, XP002952062
JEN K.Y. ET AL: "Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies", STEM CELLS, vol. 18, 2000, pages 307 - 319, XP002948605
DE BRUIJN M.H.L. ET AL: "Human complement component C3: cDNA coding sequence and derived primary structure", PROC. NATHL. ACAD. SCI., vol. 82, 1985, pages 708 - 712, XP009018561
AGRAWAL S. ET AL: "Antisense therapeutics: is it as simple as complementary base recognition", MOLECULAR MEDICINE TODAY, vol. 6, February 2000 (2000-02-01), pages 72 - 81, XP002952062
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