Title:
ANTISENSE MODULATION OF CREB EXPRESSION
Document Type and Number:
WIPO Patent Application WO2003030617
Kind Code:
A3
Abstract:
Antisense compounds, compositions and methods are provided for modulating the expression of CREB. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CREB. Methods of using these compounds for modulation of CREB expression and for treatment of diseases associated with expression of CREB are provided.
Inventors:
MONIA BRETT P
COWSERT LEX M
COWSERT LEX M
Application Number:
PCT/US2002/032181
Publication Date:
December 04, 2003
Filing Date:
October 07, 2002
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C12Q1/68; C07H21/00
Foreign References:
| US5919649A | 1999-07-06 |
Other References:
NAGAMOTO-COMBS ET AL., J. BIOL. CHEM., vol. 272, no. 9, 1997, pages 6051 - 6058, XP002969148
GONZALEZ ET AL., NATURE, vol. 337, 23 February 1989 (1989-02-23), pages 749 - 752, XP002969149
KIM ET AL., ARCH. ORAL. BIOL., vol. 46, 2001, pages 495 - 507, XP002969150
GONZALEZ ET AL., NATURE, vol. 337, 23 February 1989 (1989-02-23), pages 749 - 752, XP002969149
KIM ET AL., ARCH. ORAL. BIOL., vol. 46, 2001, pages 495 - 507, XP002969150
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