ANTISENSE MODULATION OF HISTONE DEACETYLASE 1 EXPRESSION

Title:

ANTISENSE MODULATION OF HISTONE DEACETYLASE 1 EXPRESSION

Document Type and Number:

WIPO Patent Application WO2002050244

Kind Code:

A3

Abstract:

Antisense compounds, compositions and methods are provided for modulating the expression of Histone deacetylase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Histone deacetylase 1. Methods of using these compounds for modulation of Histone deacetylase 1 expression and for treatment of diseases associated with expression of Histone deacetylase 1 are provided.

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Inventors:

MONIA BRETT P (US)
WYATT JACQUELINE R (US)

Application Number:

PCT/US2001/046518

Publication Date:

October 30, 2003

Filing Date:

December 07, 2001

Export Citation:

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Assignee:

ISIS PHARMACEUTICALS INC (US)
MONIA BRETT P (US)
WYATT JACQUELINE R (US)

International Classes:

C12N15/113; A61K38/00; (IPC1-7): C07H21/00; C12Q1/68

Foreign References:

US5763182A

1998-06-09

Other References:

TAYLOR ET AL.: "Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination", DRUG DISCOVERY TODAY, vol. 4, no. 12, December 1999 (1999-12-01), pages 562 - 567, XP002909788

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