Title:
ANTISENSE MODULATION OF HYDROXYSTEROID 11-BETA DEHYDROGENASE 1 EXPRESSION
Document Type and Number:
WIPO Patent Application WO2003088921
Kind Code:
A3
Abstract:
Antisense compounds, compositions and methods are provided for modulating the expression of hydroxysteroid 11-beta dehydrogenase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hydroxysteroid 11-beta dehydrogenase 1. Methods of using these compounds for modulation of hydroxysteroid 11-beta dehydrogenase 1 expression and for treatment of diseases associated with expression of hydroxysteroid 11-beta dehydrogenase 1 are provided.
Inventors:
FREIER SUSAN M (US)
Application Number:
PCT/US2003/012544
Publication Date:
October 14, 2004
Filing Date:
April 21, 2003
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
FREIER SUSAN M (US)
FREIER SUSAN M (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C07H21/04; A61K48/00; C12N15/00
Other References:
SOUNESS ET AL: "11beta-Hydroxysteroid dehydrogenase antisense affects vascular contractile response and glucocorticoid metabolism", STEROIDS, vol. 67, March 2002 (2002-03-01), pages 195 - 201, XP004341502
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