Title:
ANTISENSE MODULATION OF NOTCH (DROSOPHILA) HOMOLOG 4 EXPRESSION
Document Type and Number:
WIPO Patent Application WO2004035676
Kind Code:
A3
Abstract:
Antisense compounds, compositions and methods are provided for modulating the expression of Notch (Drosophila) homolog 4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Notch (Drosophila) homolog 4. Methods of using these compounds for modulation of Notch (Drosophila) homolog 4 expression and for treatment of diseases associated with expression of Notch (Drosophila) homolog 4 are provided.
Inventors:
WATT ANDREW T (US)
Application Number:
PCT/US2003/032713
Publication Date:
April 14, 2005
Filing Date:
October 16, 2003
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
WATT ANDREW T (US)
WATT ANDREW T (US)
International Classes:
C07H21/04; C12N15/113; A61K48/00; (IPC1-7): A01N43/04; A61K31/70; C07H21/04
Domestic Patent References:
| WO1998057621A1 | 1998-12-23 |
Foreign References:
| US5997341A | 1999-12-07 |
Other References:
MA D.D.F. ET AL.: "Synthetic oligonucleotides as therapeutics: the coming of age", ELSEVIER SCIENCE, 2000, BIOTECHNOLOGY ANNUAL REVIEW, vol. 5, 2000, pages 155 - 196, XP002965527
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