Title:
ANTISENSE MOLECULES AND METHOD OF CONTROLLING EXPRESSION OF GENE FUNCTION BY USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2001/096356
Kind Code:
A1
Abstract:
Antisense molecules which act on both directions of the inhibition and restoration of the expression of a gene function and are capable of on/off switching appropriately depending on the external environment; and a method of reversibly controlling the expression of a gene function by using these antisense molecules. Such an antisense molecule, which has at least one sugar-base moiety consisting of a sugar and a purine or pyrimidine base bonded thereto via a glucoside bond, can bind to a gene and/or leave therefrom under the orientation control of the base moiety in the molecule by an orientation controlling factor.
Inventors:
WADA TAKEHIKO (JP)
INOUE YOSHIHISA (JP)
INOUE YOSHIHISA (JP)
Application Number:
PCT/JP2001/005012
Publication Date:
December 20, 2001
Filing Date:
June 13, 2001
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
WADA TAKEHIKO (JP)
INOUE YOSHIHISA (JP)
WADA TAKEHIKO (JP)
INOUE YOSHIHISA (JP)
International Classes:
A61K47/04; A61P43/00; C07H19/06; C07H23/00; C12N15/113; (IPC1-7): C07H19/06; C07H19/16; A61K31/7064; A61K31/7076; A61K45/00; A61K47/02; A61K47/04; A61K47/26; A61P43/00
Other References:
TAKEHIKO WADA ET AL.: "Peptide ribonucleic acids (PRNA) 2.A Novel strategy for active control of DNA recognition through borate ester formation", J. AM. CHEM. SOC., vol. 122, no. 2, July 2000 (2000-07-01), pages 6900 - 6910, XP002944753
TAKEHIKO WADA ET AL.: "Synthesis and properties of oligo-omega-amino acids derivatives containing nucleosides", NUCLEIC ACIDS SYMPOSIUM SERIES, no. 34, 1995, pages 189 - 190, XP002944754
TAKEHIKO WADA ET AL.: "Conformational and orientational switching of uridine derivatives by borates", CHEMISTRY LETTERS, 1998, pages 1025 - 1026, XP002944755
See also references of EP 1295892A4
TAKEHIKO WADA ET AL.: "Synthesis and properties of oligo-omega-amino acids derivatives containing nucleosides", NUCLEIC ACIDS SYMPOSIUM SERIES, no. 34, 1995, pages 189 - 190, XP002944754
TAKEHIKO WADA ET AL.: "Conformational and orientational switching of uridine derivatives by borates", CHEMISTRY LETTERS, 1998, pages 1025 - 1026, XP002944755
See also references of EP 1295892A4
Attorney, Agent or Firm:
Saegusa, Eiji (Doshomachi Chuo-ku Osaka-shi, Osaka, JP)
Download PDF: