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Title:
ANTISENSE NUCLEIC ACID
Document Type and Number:
WIPO Patent Application WO/2015/194520
Kind Code:
A1
Abstract:
Provided is a drug that provides highly efficient exon skipping. The present invention provides an antisense oligomer having at least two unit oligomers linked that target arrays that are do not continue on from or overlap with each other within the same exon.

Inventors:
WATANABE Naoki (14-1, Sakura 3-chome, Tsukuba-sh, Ibaraki 03, 〒3050003, JP)
TONE Yuuichirou (14-1, Sakura 3-chome, Tsukuba-sh, Ibaraki 03, 〒3050003, JP)
TAKEDA Shin'ichi (1-1 Ogawahigashi-cho 4-chome, Kodaira-sh, Tokyo 51, 〒1878551, JP)
NAGATA Tetsuya (1-1 Ogawahigashi-cho 4-chome, Kodaira-sh, Tokyo 51, 〒1878551, JP)
Application Number:
JP2015/067238
Publication Date:
December 23, 2015
Filing Date:
June 16, 2015
Export Citation:
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Assignee:
NIPPON SHINYAKU CO., LTD. (14 Kisshoin Nishinosho Monguchicho, Minami-ku Kyoto-sh, Kyoto 50, 〒6018550, JP)
NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY (1-1 Ogawahigashi-cho 4-chome, Kodaira-shi Tokyo, 51, 〒1878551, JP)
International Classes:
C12N15/113; A61K31/712; A61K31/7125; A61K48/00; A61P21/04
Domestic Patent References:
WO2012029986A12012-03-08
WO2013100190A12013-07-04
WO2014007620A22014-01-09
WO2013112053A12013-08-01
WO2012109296A12012-08-16
WO2010123369A12010-10-28
WO2004083446A22004-09-30
WO2011057350A12011-05-19
Foreign References:
JP2008220311A2008-09-25
Other References:
SHIN'ICHI TAKEDA: "Exon Skipping Approach to Duchenne Muscular Dystorphy", SOCIETAS NEUROLOGICA JAPONICA GAKUJUTSU TAIKAI PROGRAM SHOROKUSHU, vol. 55, May 2014 (2014-05-01), pages 269, XP055244924
TETSUYA NAGATA ET AL.: "Kin Dystorphy no Idenshi Chiryo", CURR. INSIGHTS NEUROL. SCI., vol. 19 / 20, 2013, pages 20 - 21, XP008185866
See also references of EP 3159409A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (ABE IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl. 8-7, Yaesu 2-chome, Chuo-k, Tokyo 28, 〒1040028, JP)
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