Title:
ANTISENSE OLIGONUCLEIC ACID
Document Type and Number:
WIPO Patent Application WO/2018/155450
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an antisense oligonucleic acid having reduced hepatotoxicity. This antisense oligonucleic acid is characterized by: having a base length of 7-30 nt; nucleic acid residues, each of which is 1-5 nt from a respective terminal, being 2',4'-cross-linked nucleic acids; having non-2',4'-cross-linked nucleic acid residues between both terminals; and the base for at least one nucleic acid residue among the non-2',4'-cross-linked nucleic acid residues being modified.
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Inventors:
OBIKA SATOSHI (JP)
WAKI REIKO (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
MORIHIRO KUNIHIKO (JP)
KASAHARA YUYA (JP)
MIKAMI ATSUSHI (JP)
WAKI REIKO (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
MORIHIRO KUNIHIKO (JP)
KASAHARA YUYA (JP)
MIKAMI ATSUSHI (JP)
Application Number:
PCT/JP2018/006061
Publication Date:
August 30, 2018
Filing Date:
February 20, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C12N15/113; A61K31/7115; A61K31/712; A61P43/00
Domestic Patent References:
| WO2011052436A1 | 2011-05-05 | |||
| WO2014046212A1 | 2014-03-27 | |||
| WO2014112463A1 | 2014-07-24 | |||
| WO2015125783A1 | 2015-08-27 | |||
| WO2016017422A1 | 2016-02-04 | |||
| WO2013118776A1 | 2013-08-15 |
Foreign References:
| JP2016096826A | 2016-05-30 | |||
| US20150051389A1 | 2015-02-19 | |||
| US20160160280A1 | 2016-06-09 | |||
| JP2017030489A | 2017-02-09 |
Other References:
MERITS, A .: "New antisense inhibitors of hepatitis C virus", J. ANTIVIR. ANTIRETROVIR., vol. 3, no. 4, 2011, pages 165, XP055630127
MUTSO, M. ET AL.: "RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications", PLOS ONE, vol. 10, no. 6, 2015, pages e0128686, XP055555138
BURDICK, A. D. ET AL.: "Sequence motifs associated with hepatotoxicity of locked nucleic acid- modified antisense oligonucleotides", NUCLEIC ACIDS RESEARCH, vol. 42, no. 8, 2014, pages 4882 - 4891, XP055432561
PETER H. HAGEDORN ET AL., NUCLEIC ACID THERAPEUTICS, vol. 23, no. 5, 2013, pages 302 - 310
ANDREW D. BURDICK ET AL., NUCLEIC ACIDS RESEARCH, 2014, pages 1 - 10
NUCLEIC ACID THER., vol. 22, no. 5, 2012, pages 344 - 359
F. SEELA ET AL., SYNTHESIS, vol. 8, 2004, pages 1203 - 1210
M. MACKOVA ET AL., CHEMBIOCHEM, vol. 16, 2015, pages 2225 - 2236
See also references of EP 3587576A4
MUTSO, M. ET AL.: "RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications", PLOS ONE, vol. 10, no. 6, 2015, pages e0128686, XP055555138
BURDICK, A. D. ET AL.: "Sequence motifs associated with hepatotoxicity of locked nucleic acid- modified antisense oligonucleotides", NUCLEIC ACIDS RESEARCH, vol. 42, no. 8, 2014, pages 4882 - 4891, XP055432561
PETER H. HAGEDORN ET AL., NUCLEIC ACID THERAPEUTICS, vol. 23, no. 5, 2013, pages 302 - 310
ANDREW D. BURDICK ET AL., NUCLEIC ACIDS RESEARCH, 2014, pages 1 - 10
NUCLEIC ACID THER., vol. 22, no. 5, 2012, pages 344 - 359
F. SEELA ET AL., SYNTHESIS, vol. 8, 2004, pages 1203 - 1210
M. MACKOVA ET AL., CHEMBIOCHEM, vol. 16, 2015, pages 2225 - 2236
See also references of EP 3587576A4
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
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