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Title:
ANTISENSE OLIGONUCLEOTIDE CONTROLLING EXPRESSION AMOUNT OF TDP-43 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/013141
Kind Code:
A1
Abstract:
Provided are: a restraining type antisense oligonucleotide targeting TDP-43 mRNA, said antisense oligonucleotide containing a nucleotide sequence complementary to a sequence consisting of at least 10 consecutive nucleotides in a nucleotide sequence represented by any of SEQ ID NOS: 2 to 4; and an accelerating type antisense oligonucleotide targeting TDP-43 mRNA, said antisense oligonucleotide containing a nucleotide sequence complementary to a sequence consisting of at least 10 consecutive nucleotides in the nucleotide sequence represented by SEQ ID NO: 5.

Inventors:
NAGAI YOSHITAKA (JP)
MAETA KAZUHIRO (JP)
TAKEUCHI TOSHIHIDE (JP)
NEYA MASAHIRO (JP)
FUJIWARA TAKESHI (JP)
MATSUDA SEIJI (JP)
SOBUE GEN (JP)
ISHIGAKI SHINSUKE (JP)
SAHASHI KENTARO (JP)
Application Number:
PCT/JP2018/025792
Publication Date:
January 17, 2019
Filing Date:
July 06, 2018
Export Citation:
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Assignee:
UNIV OSAKA (JP)
KNC LABORATORIES CO LTD (JP)
UNIV NAGOYA NAT UNIV CORP (JP)
International Classes:
C12N15/113; A61K31/712; A61K48/00; A61P25/28
Domestic Patent References:
WO2014077693A12014-05-22
WO2016088797A12016-06-09
WO2016006697A12016-01-14
WO2007026485A12007-03-08
WO2004080406A22004-09-23
Foreign References:
US20110321179A12011-12-29
JP2017071572A2017-04-13
JP2002241393A2002-08-28
JP2000297097A2000-10-24
US3687808A1972-08-29
JP2017134890A2017-08-03
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See also references of EP 3653711A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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