Title:
ANTISENSE-OLIGONUCLEOTIDES FOR THE TREATMENT OF IMMUNOSUPPRESSIVE EFFECTS OF TRANSFORMING GROWTH FACTOR- BETA (TGF- BETA )
Document Type and Number:
WIPO Patent Application WO1994025588
Kind Code:
A3
Abstract:
Antisense-oligonucleotides or effective derivatives thereof hybridizing with an area of a gene coding for transforming growth factor-β (TGF-β) comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 1-56 and 137 or comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 57 to 136 each of the nucleic acids having a DNA- or RNA-type structure.
Inventors:
SCHLINGENSIEPEN GEORG-FERDINAN (DE)
BRYSCH WOLFGANG (DE)
SCHLINGENSIEPEN KARL-HERMANN (DE)
SCHLINGENSIEPEN REIMAR (DE)
BOGDAHN ULRICH (DE)
BRYSCH WOLFGANG (DE)
SCHLINGENSIEPEN KARL-HERMANN (DE)
SCHLINGENSIEPEN REIMAR (DE)
BOGDAHN ULRICH (DE)
Application Number:
PCT/EP1994/001362
Publication Date:
December 22, 1994
Filing Date:
April 29, 1994
Export Citation:
Assignee:
BIOGNOSTIK GES (DE)
SCHLINGENSIEPEN GEORG FERDINAN (DE)
BRYSCH WOLFGANG (DE)
SCHLINGENSIEPEN KARL HERMANN (DE)
SCHLINGENSIEPEN REIMAR (DE)
BOGDAHN ULRICH (DE)
SCHLINGENSIEPEN GEORG FERDINAN (DE)
BRYSCH WOLFGANG (DE)
SCHLINGENSIEPEN KARL HERMANN (DE)
SCHLINGENSIEPEN REIMAR (DE)
BOGDAHN ULRICH (DE)
International Classes:
A61K31/70; A61K31/7088; A61K48/00; A61P7/00; C12N15/09; A61P35/00; A61P37/04; C07H21/02; C07H21/04; C12N15/113; (IPC1-7): C12N15/11; A61K31/70; C07H21/00; A61K48/00
Other References:
JACHIMCZAK, P. ET AL: "TGF-BETA-PHOSPHOROTHIOATE-ANTISENSE OLIGONUCLEOTIDES MAY REVERSE IMMUNOSUPPRESSIVE EFFECTS OF TGF-BETA IN MALIGNANT GLIOMAS IN VITRO", PROCEEDINGS OF THE 82ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, HOUSTON, TEXAS, USA, MAY 15-18, 1991. PROC AM ASSOC CANCER RES ANNU MEET 32 (0). 1991. 248
BEHL C ET AL: "TRANSFORMING GROWTH FACTOR - BETA - ANTISENSE -OLIGONUCLEOTIDES INHIBIT A HUMAN MELANOMA CELL LINE UNDER SERUM-ENRICHED AND STIMULATE UNDER SERUM-FREE CULTURE CONDITIONS.", PROCEEDINGS OF THE 82ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, HOUSTON, TEXAS, USA, MAY 15-18, 1991. PROC AM ASSOC CANCER RES ANNU MEET 32 (0). 1991. 427.
HATZFIELD J ET AL: "RELEASE OF EARLY HUMAN HEMATOPOIETIC PROGENITORS FROM QUIESCENCE BY ANTISENSE TRANSFORMING GROWTH FACTOR BETA -1 OR RB OLIGONUCLEOTIDES.", J EXP MED 174 (4). 1991. 925-930.
BODMER, S. ET AL.: "Immunosuppression and transforming growth factor-beta in glioblastoma", JOURNAL OF IMMUNOLOGY, vol. 143, no. 10, 15 November 1989 (1989-11-15), BALTIMORE US, pages 3222 - 3229
POTTS, J ET AL.: "Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by modified antisense oligodeoxynucleotide to transforming growth factor beta3", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 88, February 1991 (1991-02-01), WASHINGTON US, pages 1516 - 1520
BEHL C ET AL: "TRANSFORMING GROWTH FACTOR - BETA - ANTISENSE -OLIGONUCLEOTIDES INHIBIT A HUMAN MELANOMA CELL LINE UNDER SERUM-ENRICHED AND STIMULATE UNDER SERUM-FREE CULTURE CONDITIONS.", PROCEEDINGS OF THE 82ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, HOUSTON, TEXAS, USA, MAY 15-18, 1991. PROC AM ASSOC CANCER RES ANNU MEET 32 (0). 1991. 427.
HATZFIELD J ET AL: "RELEASE OF EARLY HUMAN HEMATOPOIETIC PROGENITORS FROM QUIESCENCE BY ANTISENSE TRANSFORMING GROWTH FACTOR BETA -1 OR RB OLIGONUCLEOTIDES.", J EXP MED 174 (4). 1991. 925-930.
BODMER, S. ET AL.: "Immunosuppression and transforming growth factor-beta in glioblastoma", JOURNAL OF IMMUNOLOGY, vol. 143, no. 10, 15 November 1989 (1989-11-15), BALTIMORE US, pages 3222 - 3229
POTTS, J ET AL.: "Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by modified antisense oligodeoxynucleotide to transforming growth factor beta3", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 88, February 1991 (1991-02-01), WASHINGTON US, pages 1516 - 1520
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