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Title:
ANTITRYPANOSOMAL ACTIVE SUBSTANCE ACTINOALLOLIDES AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2014/112387
Kind Code:
A1
Abstract:
The purpose of the invention is to provide a novel antitrypanosomal drug. The invention pertains to actinoallolides (A, B, C, D, and/or E), which are novel compounds produced by the actinomycete MK 10-036; to a method for producing said compounds, the method being characterized in that microorganisms belonging to the actinomycetes having the ability to produce said compounds are cultured in medium, and the compounds are made to accumulate in the culture and are collected from the culture; to a trypanosome growth inhibitor containing the actinoallolides (A, B, C, D, and/or E) as an active ingredient; to a drug for the treatment or prevention of conditions caused by trypanosome infection; and the like.

Inventors:
OMURA, Satoshi (9-1 Shirokane 5-chome, Minato-k, Tokyo 41, 〒1088641, JP)
TAKAHASHI, Yoko (9-1 Shirokane 5-chome, Minato-k, Tokyo 41, 〒1088641, JP)
OTOGURO, Kazuhiko (9-1 Shirokane 5-chome, Minato-k, Tokyo 41, 〒1088641, JP)
INAHASHI, Yuki (9-1 Shirokane 5-chome, Minato-k, Tokyo 41, 〒1088641, JP)
IWATSUKI, Masato (9-1 Shirokane 5-chome, Minato-k, Tokyo 41, 〒1088641, JP)
MATSUMOTO, Atsuko (9-1 Shirokane 5-chome, Minato-k, Tokyo 41, 〒1088641, JP)
PANBANGRED, Watanalai (999 Phuttamonthon 4 Road Salay, Nakhon Pathom ., 73170, TH)
Application Number:
JP2014/000229
Publication Date:
July 24, 2014
Filing Date:
January 17, 2014
Export Citation:
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Assignee:
THE KITASATO INSTITUTE (9-1 Shirokane 5-chome, Minato-ku Tokyo, 41, 〒1088641, JP)
MAHIDOL UNIVERSITY (999 Phuttamonthon 4 Road, Salaya Nakhon Pathom, 73170, TH)
International Classes:
C07D493/08; A61K31/365; A61P33/00; C12N1/20; C12P17/18; C12R1/01
Foreign References:
JP2011178738A
JP2010018562A
Other References:
HASHIDA J. ET AL.: 'Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp.K07-0010' J. ANTIBIOT. vol. 65, no. 4, April 2012, pages 197 - 202
INAHASHI Y. ET AL.: 'Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T' J. ANTIBIOT. vol. 64, no. 4, April 2011, pages 303 - 307
Attorney, Agent or Firm:
HASEGAWA, Hiroshi et al. (Yokohama Yusen Building 2nd Floor 3-9, Kaigan-dori, Naka-ku, Yokohama-sh, Kanagawa 02, 〒2310002, JP)
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