Title:
ANTITUMOR AGENT AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2014/102889
Kind Code:
A1
Abstract:
The present invention provides: a very highly effective antitumor agent which has an extremely high effect especially on various leukemia, lymphoma and solid cancers including refractory ATL; and a method for producing the antitumor agent. A compound represented by general formula (I) (excluding a compound represented by formula (D)). (In formula (I), R1 represents a phenyl group that is substituted by at least one group selected from among a hydroxyl group, a methoxy group, a methylenedioxy group and a phosphoric acid group; R2 represents one group selected from among a hydrogen atom, a hydroxyl group, a methoxy group, an acetyl group, an anilino group and groups represented by formulae (II); R3 represents one group selected from among a hydrogen atom, a hydroxyl group, a methoxy group and an acetyl group; and R4 represents one group selected from among a hydrogen atom, a hydroxyl group, a methoxy group and an acetyl group.)
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Inventors:
ARIMA NAOMICHI (JP)
WHITE YOHANN (JP)
HAMADA TOSHIYUKI (JP)
NAKASHIMA MITSUYOSHI (JP)
WHITE YOHANN (JP)
HAMADA TOSHIYUKI (JP)
NAKASHIMA MITSUYOSHI (JP)
Application Number:
PCT/JP2012/083379
Publication Date:
July 03, 2014
Filing Date:
December 25, 2012
Export Citation:
Assignee:
UNIV KAGOSHIMA (JP)
International Classes:
C07D493/04; A23L1/30; A61K31/343; A61P35/00; A61P35/02
Foreign References:
| JP2013006821A | 2013-01-10 | |||
| JP2001131182A | 2001-05-15 | |||
| JP2005500300A | 2005-01-06 |
Other References:
TOSHIYUKI HAMADA ET AL.: "The bioassay-guided isolation of growth inhibitors of adult T- Cell leukemia(ATL), from the Jamaican plant Hyptis verticillata, and NMR characterization of Hyptoside", MOLECULES, 17 August 2012 (2012-08-17), pages 9931 - 9938
MAKOTO YOSHIMITSU ET AL.: "A novel cytotoxic agent, 4-MTDND, induces apoptosis and overcomes multidrug resistance against ATLL", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 53, no. 9, 30 September 2012 (2012-09-30), pages 1360
YOHANN WHITE ET AL.: "Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance", ANTICANCER RESEARCH, vol. 31, no. 12, December 2011 (2011-12-01), pages 4251 - 4258
H. LOPEZ ET AL.: "Lignans from Bupleurum Handiense", JOURNAL OF NATURAL PRODUCTS, vol. 59, no. 5, 1996, pages 493 - 494
ADEL AMER ET AL.: "Total synthesis of (±)- Meridinol, (±)-Epimeridinol, and a related cycloliganan", JOURNAL OF NATURAL PRODUCTS, vol. 56, no. 4, 1993, pages 600 - 605
YONG HE ET AL.: "Effects of podophyllotoxin analogues with different structures of ring c on antitumor activities", ZHONGGUO YAOWU HUAXUE ZAZHI, vol. 11, no. 1, 2001, pages 9 - 12, XP008116519
K. M. LOKANATHA RAI ET AL.: "Biological assay and antimitotic activity of novel analogues of beta-apopicropodophyllin", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 69, no. 1, 2007, pages 116 - 118
S. SHASHIKANTH ET AL.: "Synthesis of podophyllotoxin and related analogues: part IX. Synthesis of ethylenedioxy and indan analogues of picropodophyllone and their antimitotic activity", INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, pages 185 - 188
MAKOTO YOSHIMITSU ET AL.: "A novel cytotoxic agent, 4-MTDND, induces apoptosis and overcomes multidrug resistance against ATLL", THE JAPANESE JOURNAL OF CLINICAL HEMATOLOGY, vol. 53, no. 9, 30 September 2012 (2012-09-30), pages 1360
YOHANN WHITE ET AL.: "Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance", ANTICANCER RESEARCH, vol. 31, no. 12, December 2011 (2011-12-01), pages 4251 - 4258
H. LOPEZ ET AL.: "Lignans from Bupleurum Handiense", JOURNAL OF NATURAL PRODUCTS, vol. 59, no. 5, 1996, pages 493 - 494
ADEL AMER ET AL.: "Total synthesis of (±)- Meridinol, (±)-Epimeridinol, and a related cycloliganan", JOURNAL OF NATURAL PRODUCTS, vol. 56, no. 4, 1993, pages 600 - 605
YONG HE ET AL.: "Effects of podophyllotoxin analogues with different structures of ring c on antitumor activities", ZHONGGUO YAOWU HUAXUE ZAZHI, vol. 11, no. 1, 2001, pages 9 - 12, XP008116519
K. M. LOKANATHA RAI ET AL.: "Biological assay and antimitotic activity of novel analogues of beta-apopicropodophyllin", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 69, no. 1, 2007, pages 116 - 118
S. SHASHIKANTH ET AL.: "Synthesis of podophyllotoxin and related analogues: part IX. Synthesis of ethylenedioxy and indan analogues of picropodophyllone and their antimitotic activity", INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, pages 185 - 188
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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