Title:
ANTITUMOR AGENTS
Document Type and Number:
WIPO Patent Application WO/2002/009719
Kind Code:
A1
Abstract:
Antitumor agents comprising as the active ingredient a compound selected from among maslinic acid, erythrodiol, uvaol, betulinic acid, betulin, physiologically acceptable salts thereof and derivatives thereof.
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Inventors:
KUNO NORIYASU (JP)
SHINOHARA GOU (JP)
INUI TOSIYUKI (JP)
SHINOHARA GOU (JP)
INUI TOSIYUKI (JP)
Application Number:
PCT/JP2001/006393
Publication Date:
February 07, 2002
Filing Date:
July 25, 2001
Export Citation:
Assignee:
NISSHIN OIL MILLS LTD (JP)
KUNO NORIYASU (JP)
SHINOHARA GOU (JP)
INUI TOSIYUKI (JP)
KUNO NORIYASU (JP)
SHINOHARA GOU (JP)
INUI TOSIYUKI (JP)
International Classes:
A61K31/047; A61K31/19; A61K31/191; A61P35/00; C07J53/00; (IPC1-7): A61K31/56; A61K35/78; A61P35/00; C07J53/00
Foreign References:
US5985924A | 1999-11-16 | |||
JPS6360949A | 1988-03-17 | |||
JPS6357519A | 1988-03-12 | |||
JPH01143832A | 1989-06-06 | |||
US5962527A | 1999-10-05 |
Other References:
KEN YASUKAWA ET AL.: "Antitumor-promoting activities of sterols and triterpenoids", NIPPON YUKA GAKKAI-SHI, vol. 49, no. 6, 20 June 2000 (2000-06-20), pages 571 - 583, XP002948553
YOUNG-KYOON KIM ET AL.: "Cytotoxic triterpenes from stembark of physocarpus intermedius", PLANTA MED., vol. 66, no. 5, June 2000 (2000-06-01), pages 485 - 486, XP002948554
D. ES-SAADY ET AL.: "Effects of ursolic acid and its analogues on soybean 15-lipoxigenase activity and the proliferation rate of a human gastric tumor cell line", MEDIATORS OF INFLAMMATION, vol. 3, 1994, pages 181 - 184, XP002948555
See also references of EP 1321145A4
YOUNG-KYOON KIM ET AL.: "Cytotoxic triterpenes from stembark of physocarpus intermedius", PLANTA MED., vol. 66, no. 5, June 2000 (2000-06-01), pages 485 - 486, XP002948554
D. ES-SAADY ET AL.: "Effects of ursolic acid and its analogues on soybean 15-lipoxigenase activity and the proliferation rate of a human gastric tumor cell line", MEDIATORS OF INFLAMMATION, vol. 3, 1994, pages 181 - 184, XP002948555
See also references of EP 1321145A4
Attorney, Agent or Firm:
Nakamura, Minoru (Marunouchi 3-Chome Chiyoda-Ku, Tokyo, JP)
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