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Title:
ANTITUMOR COMPOSITION OR ANTITUMOR IMMUNITY-INDUCING COMPOSITION COMPRISING ERYSIMUM SP. EXTRACT AS EFFECTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/056772
Kind Code:
A1
Abstract:
The present invention relates to an antitumor composition or antitumor immunity-inducing composition comprising an Erysimum sp. extract as an effective ingredient. In the present invention, it is particularly found that Erysimum cheiranthoides and Erysimum macilentum extracts not only have anticancer activity against various carcinomas but also increase calreticulin (CRT) expression and ATP release on a cancer cell surface. Accordingly, the present invention ascertains that cancer cells killed by an Erysimum sp. extract act as an antigen and activate dendritic cells to induce antitumor immunity.

Inventors:
YI JIN-MU (KR)
BANG OK-SUN (KR)
KIM JIN HEE (KR)
KIM NO SOO (KR)
LEE YOU JIN (KR)
KIM YOUNG-AH (KR)
Application Number:
PCT/KR2017/010532
Publication Date:
March 29, 2018
Filing Date:
September 25, 2017
Export Citation:
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Assignee:
KOREA INST ORIENTAL MEDICINE (KR)
International Classes:
A61K36/28; A23L33/105; A61K9/16; A61K9/20; A61K9/48
Foreign References:
CN104474327A2015-04-01
KR20150084488A2015-07-22
KR20130057145A2013-05-31
KR20150135036A2015-12-02
Other References:
DAI, S.-X.: "In silico identification of anti cancer compounds and plants from traditional Chinese medicine database", SCIENTIFIC REPORTS, vol. 6, no. 25462, 5 May 2016 (2016-05-05), pages 1 - 9, XP055603513, ISSN: 2045-2322, DOI: 10.1038/srep25462
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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