ANTITUMOR INDOLOPYRROLOCARBAZOLES

WIPO Patent Application WO/1996/004293

A1

A compound represented by general formula [1] or a pharmaceutically acceptable salt thereof, having an excellent antitumor effect, and hence being useful as an antitumor agent, wherein X1 and X2 represent each independently hydrogen, halogen, amino, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, lower alkoxy, aralkoxy, carboxy, lower alkoxycarbonyl, lower alkanoyloxy, or lower alkyl which may be substituted by one or two hydroxy groups; R1 represents hydrogen, amino, formylamino, lower alkanoylamino, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, lower alkoxy, aralkoxy, aralkyl, lower alkylcarbonyl, arylcarbonyl or lower alkyl (wherein the lower alkanoylamino, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkoxy, aralkoxy, aralkyl, lower alkylcarbonyl, arylcarbonyl and lower alkyl may be substituted by one to five groups selected from among carboxy, carbamoyl, sulfo, amino, cyano, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, heterocycle which may be substituted by one to three hydroxy groups or by lower alkyl which may be substituted by one to three hydroxy groups, and halogen atoms); and R2 represents a disaccharide group.

KOJIRI KATSUHISA (JP)
SHIMOKAWA HARUKI (JP)
OHKUBO MITSURU (JP)
KAWAMURA KENJI (JP)
KONDO HISAO (JP)
ARAKAWA HIROHARU (JP)
SUDA HIROYUKI (JP)

PCT/JP1995/001490

February 15, 1996

July 26, 1995

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BANYU PHARMA CO LTD (JP)
KOJIRI KATSUHISA (JP)
SHIMOKAWA HARUKI (JP)
OHKUBO MITSURU (JP)
KAWAMURA KENJI (JP)
KONDO HISAO (JP)
ARAKAWA HIROHARU (JP)
SUDA HIROYUKI (JP)

C07H19/04; C07H19/052; C12P19/26; (IPC1-7): C07H19/23; A61K31/70; C12P19/38

JPH06128283A	1994-05-10
JPH06296494A	1994-10-25

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