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Patent Searching and Data


Title:
ANTITUMOR PROTEIN COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/149039
Kind Code:
A1
Abstract:
An antitumor pharmaceutical composition, comprising proteins IL12, GMCSF, and IL2. The present invention has technical effects of effectively inhibiting tumors at various stages with mild adverse reactions.

Inventors:
ZHANG, Jinyu (No. 301-198, Dongyi District Third Floor, Building 6, Guochuang Industrial Park, Laiguangying West Road, Chaoyang District, Beijing 2, 100012, CN)
Application Number:
CN2019/070994
Publication Date:
August 08, 2019
Filing Date:
January 09, 2019
Export Citation:
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Assignee:
BEIJING KENUOKEFU BIOTECHNOLOGY CO., LTD. (No. 301-198, Dongyi District Third Floor, Building 6, Guochuang Industrial Park, Laiguangying West Road, Chaoyang District, Beijing 2, 100012, CN)
International Classes:
A61K38/20; A61P35/00; A61P35/04
Domestic Patent References:
WO2015189356A12015-12-17
Foreign References:
CN108686202A2018-10-23
CN106795527A2017-05-31
CN105307671A2016-02-03
Other References:
INDROVA, M. ET AL.: "Chemoimmunotherapy in Mice Carrying HPV16-associated, MHC Class I+ and Class I- tumours: Effects of CBM-4A Potentiated with IL -2, IL -12, GM-CSF and Genetically Modified Tumour Vaccines", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 22, no. 3, March 2003 (2003-03-01) - 31 December 2003 (2003-12-31), pages 691 - 695, XP055628649
MIGUEL, A. ET AL.: "Comparative Antitumor Effect among GM-CSF, IL -12 and GM-CSF + IL -12 Genetically Modified Tumor Cell Vaccines", CANCER GENE THERAPY, vol. 20, 23 August 2003 (2003-08-23), pages 576 - 581, XP055095898, doi:10.1038/cgt.2013.54
LI, LAN ET AL.: "Effects of IL-21 Alone or in Combination with IL-15/IL-2 on Proliferation and Anti-tumor Activity of G-CSF-Mobilized Peripheral Blood Mononuclear Cells In Vitro", JOURNAL OF EXPERIMENTAL HEMATOLOGY, vol. 16, no. 2, 31 December 2008 (2008-12-31), pages 350 - 354
WEN, QIAN ET AL.: "Effect of Bifunctional IL2-GMCSF in Promoting Dendritic Cell Activition In Vitro in Simulated Tumor-Induced Immune Suppression", JOURNAL OF SOUTHERN MEDICAL UNIVERSITY, vol. 35, no. 9, 31 December 2015 (2015-12-31), pages 1239 - 1244
WEISS, J.M. ET AL.: "Immunotherapy of Cancer by IL -12-based Cytokine Combinations", E XPERT OPIN BIOL THER., vol. 7, no. 11, 30 November 2007 (2007-11-30), pages 1705 - 1721, XP055007188, doi:10.1517/14712598.7.11.1705
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. et al. (Room 1101, Sky-lotus Mansion Lotus-pond East Road, Xicheng District, Beijing 0, 100000, CN)
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