Title:
ANTIVIRAL AGENT COMPRISING RNA OLIGONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2017/065405
Kind Code:
A1
Abstract:
The present invention relates to an antiviral agent comprising an RNA oligonucleotide having particular sequence and structure. More particularly, when an RNA oligonucleotide having a particular sequence and a bent helix structure, according to the present invention, is treated in the cell line, interferon-β or ISG56 expression is increased and antiviral activity occurs. Therefore, a composition comprising the RNA oligonucleotide can be utilized as an antiviral agent.
Inventors:
CHOI BYONG-SEOK (KR)
LEE JANGHYUN (KR)
LEE JANGHYUN (KR)
Application Number:
PCT/KR2016/009601
Publication Date:
April 20, 2017
Filing Date:
August 29, 2016
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K48/00; A61K31/713; C12N15/113
Domestic Patent References:
| WO2013162350A2 | 2013-10-31 |
Foreign References:
| US20040170963A1 | 2004-09-02 | |||
| US20120121551A1 | 2012-05-17 | |||
| KR20050084693A | 2005-08-26 | |||
| US20120288476A1 | 2012-11-15 | |||
| US20120121551A1 | 2012-05-17 |
Other References:
MA, Y. ET AL.: "RNA Interference and Antiviral Therapy", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 13, no. 39, 2007, pages 5169 - 5179, XP055375737
ANDREJEVA, J. ET AL.: "ISG56/IFIT1 is Primarily Responsible for Interferon-induced Changes to Patterns of Parainfluenza Virus Type 7 Transcription and Protein Synthesis", JOURNAL OF GENERAL VIROLOGY, vol. 94, 2013, pages 59 - 68, XP055375739
GROSS G ET AL., DERMATOLOGY, vol. 196, no. 3, 1998, pages 330 - 4
ANDREJEVA, J. ET AL.: "ISG56/IFIT1 is Primarily Responsible for Interferon-induced Changes to Patterns of Parainfluenza Virus Type 7 Transcription and Protein Synthesis", JOURNAL OF GENERAL VIROLOGY, vol. 94, 2013, pages 59 - 68, XP055375739
GROSS G ET AL., DERMATOLOGY, vol. 196, no. 3, 1998, pages 330 - 4
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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