Title:
ANTIVIRAL INHIBITIONS OF CAPSID PROTEINS
Document Type and Number:
WIPO Patent Application WO2003089615
Kind Code:
A3
Abstract:
Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a compound that binds to the apical cleft near the C-terminal end of the N-terminal domain of the HIV-1 capsid protein are provided. Derivatives of CAP-1, CAP-2, CAP-3, CAP-4, CAP-5, CAP-6 and CAP-7 are described that bind to the apical cleft of the N-terminal domain of the HIV-1 capsid protein and inhibit proper assembly of the core particle.
Inventors:
SUMMERS MICHAEL F
TANG CHUN
HUANG MINGJUN
TANG CHUN
HUANG MINGJUN
Application Number:
PCT/US2003/012260
Publication Date:
March 11, 2004
Filing Date:
April 22, 2003
Export Citation:
Assignee:
UNIV MARYLAND (US)
International Classes:
G01N33/50; A61K31/00; A61K31/17; A61K31/277; A61K31/341; A61K45/00; A61P31/18; A61P43/00; C07C275/30; C07C275/32; C07C275/40; C07C275/42; C07C281/06; C07D307/52; C07K14/16; C12Q1/18; G01N33/15; G06F19/00; G16B15/20; G16B35/20; (IPC1-7): C12Q1/70; C12Q1/58; A61K39/21
Foreign References:
| US20010036627A1 | 2001-11-01 | |||
| US20030104577A1 | 2003-06-05 | |||
| US20020094523A1 | 2002-07-18 |
Other References:
TANG C. ET AL.: "Antiviral inhibition of the HIV-1 capsid protein", J. MOL. BIOL., vol. 327, no. 5, April 2003 (2003-04-01), pages 1013 - 1020, XP004457592
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