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Title:
ANTIVIRAL NUCLEOSIDE ANALOGS
Document Type and Number:
WIPO Patent Application WO/2010/036407
Kind Code:
A3
Abstract:
The invention provides compounds as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds are useful as anti-viral agents and/or as anti-cancer agents.

Inventors:
BABU YARLAGADDA S (US)
CHAND POORAN (US)
KUMAR V SATISH (US)
HU XINGDING (US)
Application Number:
PCT/US2009/044214
Publication Date:
May 20, 2010
Filing Date:
May 15, 2009
Export Citation:
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Assignee:
BIOCRYST PHARM INC (US)
BABU YARLAGADDA S (US)
CHAND POORAN (US)
KUMAR V SATISH (US)
HU XINGDING (US)
International Classes:
A61K31/53; A61K31/519; A61P31/12; A61P35/00; C07H7/06; C07H19/23
Domestic Patent References:
WO2000056734A12000-09-28
WO2007038314A22007-04-05
WO2008116064A22008-09-25
WO2008141079A12008-11-20
Other References:
IUPAC: "nucleosides", 1995, XP002571754, Retrieved from the Internet [retrieved on 20100305]
DUDFIELD P J ET AL: "SYNTHESIS OF C-RIBOSYL IMIDAZO not 2,1-F 3/4 not 1,2,4 3/4 TRIAZINES AS INHIBITORSOF ADENOSINE AND AMP DEAMINASES", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, vol. 1, no. 20, 1 January 1999 (1999-01-01), pages 2929 - 2936, XP000917128, ISSN: 0300-922X
GLEESON, M.P.; BURTON, N.A.; HILLIER, I.H.: "Prediction of the potency of inhibitors of adenosines deaminase by QM/MM calculations", CHEMICAL COMMUNICATIONS, vol. 2003, 2003, pages 2180 - 2181, XP002571755, ISSN: 1364-548X
KOBE B ET AL: "Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nucleosides", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 27, no. 3, 1 April 1992 (1992-04-01), pages 259 - 266, XP023870223, ISSN: 0223-5234, [retrieved on 19920401]
FAUCI, A.S.; BRAUNWALD, E.; ISSELBACHER, K.J.; WILSON, J.D.; MARTIN, J.B.; KASPER, D.L.; HAUSER, S.L.; LONGO, D.L.: "Harrison's Principles of Internal Medicine", 1998, MCGRAW-HILL, ISBN: 0070202915, pages: 1070, XP002571756
Attorney, Agent or Firm:
MALEN, Peter L. et al. (P.O. Box 111098Saint Paul, Minnesota, US)
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