Title:
APIXABAN PURIFICATION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/239735
Kind Code:
A1
Abstract:
Provided is an industrially applicable apixaban purification method whereby high removability of analogous substances and a good re-crystallization yield are achieved. This apixaban purification method is characterized in that a base is added to apixaban in a mixed solvent of acetonitrile and water to be re-crystallized, and the base to be used is selected from potassium carbonate, potassium bicarbonate, potassium hydroxide, sodium carbonate, sodium hydrogen carbonate, sodium hydroxide, sodium methoxide, ammonia water, and triethylamine. The purification method achieves high removability of analogous substances and high purification efficiency.
Inventors:
HORI YOHEI (JP)
CHUDA YU (JP)
CHUDA YU (JP)
Application Number:
PCT/JP2022/019678
Publication Date:
November 17, 2022
Filing Date:
May 09, 2022
Export Citation:
Assignee:
DAITO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D471/04; A61K31/4545; A61P7/02; A61P43/00
Foreign References:
| CN106279149A | 2017-01-04 | |||
| CN105985336A | 2016-10-05 | |||
| IN487MU2015A | 2016-08-31 |
Attorney, Agent or Firm:
KUSAMA, Osamu (JP)
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