Title:
APO-A CONJUGATES FOR THE ADMINISTRATION OF BIOLOGICALLY ACTIVE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2009/150284
Kind Code:
A3
Abstract:
The invention relates to a conjugate comprising a molecule of Apo A or a functionally equivalent variant thereof and a compound of therapeutic interest wherein both components are covalently bonded, and also to the uses of said conjugates in therapy for the specific direction of said compounds to those tissues having specific bonding sites for the molecule of ApoA.
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Inventors:
PRIETO VALTUENA JESUS MARIA (ES)
BERRAONDO LOPEZ PEDRO (ES)
FIORAVANTI JESSICA (ES)
BERRAONDO LOPEZ PEDRO (ES)
FIORAVANTI JESSICA (ES)
Application Number:
PCT/ES2009/070224
Publication Date:
December 09, 2010
Filing Date:
June 12, 2009
Export Citation:
Assignee:
PROYECTO BIOMEDICINA CIMA SL (ES)
PRIETO VALTUENA JESUS MARIA (ES)
BERRAONDO LOPEZ PEDRO (ES)
FIORAVANTI JESSICA (ES)
PRIETO VALTUENA JESUS MARIA (ES)
BERRAONDO LOPEZ PEDRO (ES)
FIORAVANTI JESSICA (ES)
International Classes:
A61K47/48
Domestic Patent References:
| WO2008007146A1 | 2008-01-17 | |||
| WO2004041179A2 | 2004-05-21 | |||
| WO2005070400A1 | 2005-08-04 | |||
| WO1987002061A1 | 1987-04-09 | |||
| WO2009036460A2 | 2009-03-19 |
Foreign References:
| US20060252694A1 | 2006-11-09 | |||
| US20080138394A1 | 2008-06-12 | |||
| US20080206142A1 | 2008-08-28 | |||
| US20090110739A1 | 2009-04-30 |
Other References:
KREUTER ET AL: "Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.JCONREL.2006.12.012, vol. 118, no. 1, 24 February 2007 (2007-02-24), pages 54 - 58, XP005903632, ISSN: 0168-3659
CORBIN I R ET AL: "Enhanced cancer-targeted delivery using engineered high-density lipoprotein-based nanocarriers", JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, vol. 3, no. 4, December 2007 (2007-12-01), pages 367 - 376, XP007914544, DOI: 10.1166/JBN.2007.053
SKIBA P J ET AL: "Interferon-[gamma] down-regulates the lipoprotein(a)/apoprotein(a) receptor activity on macrophage foam cells. Evidence for disruption of ligand-induced receptor recycling by interferon-[gamma]", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 37, 1994, pages 23059 - 23067, XP002597774, ISSN: 0021-9258
GLASS C K ET AL: "TISSUE SITES OF DEGRADATION OF APO PROTEIN A-I IN THE RAT", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 11, 1983, pages 7161 - 7167, XP002597775, ISSN: 0021-9258
KREUTER J ET AL: "APOLIPOPROTEIN-MEDIATED TRANSPORT OF NANOPARTICLE-BOUND DRUGS ACROSS THE BLOOD-BRAIN BARRIER", JOURNAL OF DRUG TARGETING, HARWOOD ACADEMIC PUBLISHERS GMBH, DE LNKD- DOI:10.1080/10611860290031877, vol. 10, no. 4, 1 June 2002 (2002-06-01), pages 317 - 325, XP009027368, ISSN: 1061-186X
D'ARONDEL C ET AL: "A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers", JOURNAL OF VIRAL HEPATITIS, vol. 13, no. 3, March 2006 (2006-03-01), pages 182 - 189, XP002597776, DOI: 10.1111/J.1365-2893.2005.00668.X
SANTIAGO BEGONA ET AL: "Topical application of a peptide inhibitor of transforming growth factor-beta 1 ameliorates bleomycin-induced skin fibrosis", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 125, no. 3, September 2005 (2005-09-01), pages 450 - 455, XP002604583, ISSN: 0022-202X
DOTOR ET AL: "Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US LNKD- DOI:10.1016/J.CYTO.2007.06.004, vol. 39, no. 2, 6 October 2007 (2007-10-06), pages 106 - 115, XP022289351, ISSN: 1043-4666
SATO Y. ET AL.: "Lipoprotein(a) induces cell growth in rat peritoneal macrophages through inhibition of transforming growth factor-.beta. activation", ATHEROSCLEROSIS, vol. 125, no. 1, 1996, pages 15 - 26, XP002604584, ISSN: 0021-9150
MORRONE G ET AL: "EFFECT OF TGF-BETA ON LIVER GENES EXPRESSION ANTAGONISTIC EFFECT OF TGF-BETA ON IL-6-STIMULATED GENES IN HEP 3B CELLS", FEBS LETTERS, vol. 301, no. 1, 1992, pages 1 - 4, XP002604585, ISSN: 0014-5793
SEOANE J: "The TGF[beta] pathway as a therapeutic target in cancer", CLINICAL AND TRANSLATIONAL ONCOLOGY, vol. 10, no. 1, 2 February 2008 (2008-02-02), pages 14 - 19, XP002604586, ISSN: 1699-048X, DOI: 10.1007/S12094-008-0148-2
AKHURST R J: "Large- and small-molecule inhibitors of transforming growth factor-[beta] signaling", CURRENT OPINION IN INVESTIGATIONAL DRUGS, vol. 7, no. 6, June 2006 (2006-06-01), pages 513 - 521, XP008127792, ISSN: 1472-4472
MALLAT, ZIAD ET AL: "Inhibition of transforming growth factor-.beta. signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice", CIRCULATION RESEARCH, vol. 89, no. 10, 2001, pages 930 - 934, XP002604588, ISSN: 0009-7330, DOI: 10.1161/hh2201.099415
CORBIN I R ET AL: "Enhanced cancer-targeted delivery using engineered high-density lipoprotein-based nanocarriers", JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, vol. 3, no. 4, December 2007 (2007-12-01), pages 367 - 376, XP007914544, DOI: 10.1166/JBN.2007.053
SKIBA P J ET AL: "Interferon-[gamma] down-regulates the lipoprotein(a)/apoprotein(a) receptor activity on macrophage foam cells. Evidence for disruption of ligand-induced receptor recycling by interferon-[gamma]", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 37, 1994, pages 23059 - 23067, XP002597774, ISSN: 0021-9258
GLASS C K ET AL: "TISSUE SITES OF DEGRADATION OF APO PROTEIN A-I IN THE RAT", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 11, 1983, pages 7161 - 7167, XP002597775, ISSN: 0021-9258
KREUTER J ET AL: "APOLIPOPROTEIN-MEDIATED TRANSPORT OF NANOPARTICLE-BOUND DRUGS ACROSS THE BLOOD-BRAIN BARRIER", JOURNAL OF DRUG TARGETING, HARWOOD ACADEMIC PUBLISHERS GMBH, DE LNKD- DOI:10.1080/10611860290031877, vol. 10, no. 4, 1 June 2002 (2002-06-01), pages 317 - 325, XP009027368, ISSN: 1061-186X
D'ARONDEL C ET AL: "A prospective assessment of an 'a la carte' regimen of PEG-interferon alpha2b and ribavirin combination in patients with chronic hepatitis C using biochemical markers", JOURNAL OF VIRAL HEPATITIS, vol. 13, no. 3, March 2006 (2006-03-01), pages 182 - 189, XP002597776, DOI: 10.1111/J.1365-2893.2005.00668.X
SANTIAGO BEGONA ET AL: "Topical application of a peptide inhibitor of transforming growth factor-beta 1 ameliorates bleomycin-induced skin fibrosis", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 125, no. 3, September 2005 (2005-09-01), pages 450 - 455, XP002604583, ISSN: 0022-202X
DOTOR ET AL: "Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US LNKD- DOI:10.1016/J.CYTO.2007.06.004, vol. 39, no. 2, 6 October 2007 (2007-10-06), pages 106 - 115, XP022289351, ISSN: 1043-4666
SATO Y. ET AL.: "Lipoprotein(a) induces cell growth in rat peritoneal macrophages through inhibition of transforming growth factor-.beta. activation", ATHEROSCLEROSIS, vol. 125, no. 1, 1996, pages 15 - 26, XP002604584, ISSN: 0021-9150
MORRONE G ET AL: "EFFECT OF TGF-BETA ON LIVER GENES EXPRESSION ANTAGONISTIC EFFECT OF TGF-BETA ON IL-6-STIMULATED GENES IN HEP 3B CELLS", FEBS LETTERS, vol. 301, no. 1, 1992, pages 1 - 4, XP002604585, ISSN: 0014-5793
SEOANE J: "The TGF[beta] pathway as a therapeutic target in cancer", CLINICAL AND TRANSLATIONAL ONCOLOGY, vol. 10, no. 1, 2 February 2008 (2008-02-02), pages 14 - 19, XP002604586, ISSN: 1699-048X, DOI: 10.1007/S12094-008-0148-2
AKHURST R J: "Large- and small-molecule inhibitors of transforming growth factor-[beta] signaling", CURRENT OPINION IN INVESTIGATIONAL DRUGS, vol. 7, no. 6, June 2006 (2006-06-01), pages 513 - 521, XP008127792, ISSN: 1472-4472
MALLAT, ZIAD ET AL: "Inhibition of transforming growth factor-.beta. signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice", CIRCULATION RESEARCH, vol. 89, no. 10, 2001, pages 930 - 934, XP002604588, ISSN: 0009-7330, DOI: 10.1161/hh2201.099415
Attorney, Agent or Firm:
ARIAS SANZ, Juan (S.L.Avenida de Burgos, 16, Edificio Euromor Madrid, ES)
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