Title:
APOPTOSIS INDUCER
Document Type and Number:
WIPO Patent Application WO/2004/039407
Kind Code:
A1
Abstract:
It is intended to provide an apoptosis inducer or the like containing a compound or its salt inhibiting the activity of a protein having an amino acid, which is the same or substantially the same as the amino acid sequence of HTRA3, its peptide fragment or a salt thereof or the expression of the gene thereof.
Inventors:
HORIKOSHI KENICHI (JP)
KITAHARA OSAMU (JP)
WATANABE TAKAHIRO (JP)
TANIYAMA YOSHIO (JP)
NISHIZAWA SATORU (JP)
KITAHARA OSAMU (JP)
WATANABE TAKAHIRO (JP)
TANIYAMA YOSHIO (JP)
NISHIZAWA SATORU (JP)
Application Number:
PCT/JP2003/013920
Publication Date:
May 13, 2004
Filing Date:
October 30, 2003
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
HORIKOSHI KENICHI (JP)
KITAHARA OSAMU (JP)
WATANABE TAKAHIRO (JP)
TANIYAMA YOSHIO (JP)
NISHIZAWA SATORU (JP)
HORIKOSHI KENICHI (JP)
KITAHARA OSAMU (JP)
WATANABE TAKAHIRO (JP)
TANIYAMA YOSHIO (JP)
NISHIZAWA SATORU (JP)
International Classes:
A61K31/7088; A61P35/00; A61P43/00; C07K14/47; C12N15/57; C12Q1/68; (IPC1-7): A61K45/00; A61K31/7088; A61K38/17; A61K39/395; A61K48/00; A61P35/00; A61P43/00; C12N15/57; C12Q1/68; G01N33/15; G01N33/50; G01N33/566
Domestic Patent References:
| WO2000039149A2 | 2000-07-06 | |||
| WO2002032939A2 | 2002-04-25 | |||
| WO2001083775A2 | 2001-11-08 | |||
| WO2002090568A2 | 2002-11-14 |
Foreign References:
| US20030027998A1 | 2003-02-06 |
Other References:
BALDI ALFONSO, ET AL: "THE HTRA1 SERINE PROTEASE IS DOWN-REGULATED DURING HUMAN MELANOMA PROGRESSION AND REPRESSES GROWTH OF METASTATIC MELANOMA CELLS", ONCOGENE, vol. 21, no. 43, 2002, pages 6684 - 6688, XP002976435
OKA CHIO, ET AL: "MOUSE HTRA1 SERINE PROTEASE, S8 INHIBITED CHONDROGENESIS BY ANTAGONIZING BMP AND ACTIVIN", DEVELOPMENT GROWTH AND DIFFERENTATION, vol. 43, no. SUPPL., 2001, pages S144, XP002976436
HU S-I, ET AL: "HUMAN HTRA AN EVOLUTIONARILY CONSERVED SERINE PROTEASE IDENTIFIED AS DIFFERENTIALLY EXPRESSED GENE PRODUCT IN OSTEOARTHRITIC CARTILAGE", J. BIOL. CHEM., vol. 273, no. 51, 1998, pages 34406 - 34412, XP002124453
DE LUCA ANTONIO, ET AL: "DISTRIBUTION OF THE SERINE PROTEASE HTRA1 IN NORMAL HUMAN TISSUES", JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY, vol. 51, no. 10, October 2003 (2003-10-01), pages 1279 - 1284, XP002976437
NIE G-Y. ET AL: "IDENTIFICATION AND CLONING OF TWO ISOFORMS OF HUMAN HIGH-TEMPERATURE REQUIREMENT FACTOR A3 (HTRA3), CHARACTERIZATION OF ITS GENOMIC STRUCTURE AND COMPARISON OF ITS TISSUE DISTRIBUTION WITH HTRA1 AND HTRA2", BIOCHEM J, vol. 371, no. PRT 1, April 2003 (2003-04-01), pages 39 - 48, XP002976438
OKA CHIO, ET AL: "MOUSE HTRA1 SERINE PROTEASE, S8 INHIBITED CHONDROGENESIS BY ANTAGONIZING BMP AND ACTIVIN", DEVELOPMENT GROWTH AND DIFFERENTATION, vol. 43, no. SUPPL., 2001, pages S144, XP002976436
HU S-I, ET AL: "HUMAN HTRA AN EVOLUTIONARILY CONSERVED SERINE PROTEASE IDENTIFIED AS DIFFERENTIALLY EXPRESSED GENE PRODUCT IN OSTEOARTHRITIC CARTILAGE", J. BIOL. CHEM., vol. 273, no. 51, 1998, pages 34406 - 34412, XP002124453
DE LUCA ANTONIO, ET AL: "DISTRIBUTION OF THE SERINE PROTEASE HTRA1 IN NORMAL HUMAN TISSUES", JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY, vol. 51, no. 10, October 2003 (2003-10-01), pages 1279 - 1284, XP002976437
NIE G-Y. ET AL: "IDENTIFICATION AND CLONING OF TWO ISOFORMS OF HUMAN HIGH-TEMPERATURE REQUIREMENT FACTOR A3 (HTRA3), CHARACTERIZATION OF ITS GENOMIC STRUCTURE AND COMPARISON OF ITS TISSUE DISTRIBUTION WITH HTRA1 AND HTRA2", BIOCHEM J, vol. 371, no. PRT 1, April 2003 (2003-04-01), pages 39 - 48, XP002976438
Attorney, Agent or Firm:
Takahashi, Shuichi c/o Osaka Plant of TAKEDA CHEMICAL INDUSTRIES LTD. (17-85, Jusohonmachi 2-chome, Yodogawa-k, Osaka-shi Osaka, JP)
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