Title:
APOPTOSIS INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2018/014802
Kind Code:
A1
Abstract:
The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.
Inventors:
ZHANG ZHIYUAN (CN)
WANG XIAODONG (CN)
HUANG SHAOQIANG (CN)
JIANG XIAN (CN)
LI LI (CN)
ZHANG ZHAOLAN (CN)
HAN JIANGUANG (CN)
WANG XIAODONG (CN)
HUANG SHAOQIANG (CN)
JIANG XIAN (CN)
LI LI (CN)
ZHANG ZHAOLAN (CN)
HAN JIANGUANG (CN)
Application Number:
PCT/CN2017/093096
Publication Date:
January 25, 2018
Filing Date:
July 17, 2017
Export Citation:
Assignee:
NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)
International Classes:
C07D239/48; A61K9/00; A61K31/145; A61K31/505; A61P9/10; A61P25/00; A61P25/16; A61P25/28; A61P37/00
Domestic Patent References:
WO2015058160A1 | 2015-04-23 | |||
WO2008157003A2 | 2008-12-24 | |||
WO2008157003A2 | 2008-12-24 | |||
WO2004087679A1 | 2004-10-14 | |||
WO2004029204A2 | 2004-04-08 | |||
WO2004046120A2 | 2004-06-03 |
Foreign References:
US20090163545A1 | 2009-06-25 | |||
US3149109A | 1964-09-15 | |||
US20050080111A1 | 2005-04-14 | |||
GB2379218A | 2003-03-05 | |||
JP2000063378A | 2000-02-29 |
Other References:
LI LI ET AL.: "Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment", AMERICAN CHEMICAL SOCIETY, vol. 8, 1 March 2017 (2017-03-01), pages 407 - 412, XP055454810
XIAN JIANG ET AL.: "A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway", MOLECULAR CELL, vol. 63, 21 July 2016 (2016-07-21), pages 229 - 239, XP029653541
DAYONG ZHAI ET AL.: "High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1", JOURNAL OF BIOMOLECULAR SCREENING, vol. 17, no. 3, 4 October 2011 (2011-10-04), pages 350 - 360, XP055454811
ENG ET AL., DRUG METABOLISM AND DISPOSITION, vol. 41, no. 8, 2013, pages 1470 - 1479
DAYONG ZHAI ET AL.: "High-throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1", JOURNAL OF BIOMOLECULAR SCREENING, vol. 17, no. 3, 4 October 2011 (2011-10-04), pages 350 - 360, XP055454811, DOI: 10.1177/1087057111429372
XIAN JIANG ET AL.: "A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway", MOLECULAR CELL, vol. 63, 21 July 2016 (2016-07-21), pages 229 - 239, XP029653541
DAYONG ZHAI ET AL.: "High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1", JOURNAL OF BIOMOLECULAR SCREENING, vol. 17, no. 3, 4 October 2011 (2011-10-04), pages 350 - 360, XP055454811
ENG ET AL., DRUG METABOLISM AND DISPOSITION, vol. 41, no. 8, 2013, pages 1470 - 1479
DAYONG ZHAI ET AL.: "High-throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1", JOURNAL OF BIOMOLECULAR SCREENING, vol. 17, no. 3, 4 October 2011 (2011-10-04), pages 350 - 360, XP055454811, DOI: 10.1177/1087057111429372
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