APOPTOSIS REGULATOR - OTSUKA PHARMA CO LTD

Title:

APOPTOSIS REGULATOR

Document Type and Number:

WIPO Patent Application WO/1994/004504

Kind Code:

A1

Abstract:

Carbostyril derivatives represented by general formula (1), salts thereof, and an apoptosis regulator containing the same as the active ingredient, wherein R represents benzoyl, phenyl-substituted lower alkyl, etc.; R20 represents hydrogen, lower alkyl, etc.; and R21 represents hydrogen, lower alkyl, etc. The regulator is useful as antitumor agent, antiretroviral agent, autoimmune disease remedy, immunosuppressant, Alzheimer\'s disease remedy, hepatic disease remedy, cancer metastasis inhibitor, and so forth.

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Inventors:

NAKAI SATORU (JP)
AIHARA KOUTOKU (JP)
TANAKA HIDEO (JP)
IBA HITOMI (JP)
KAWAI KAZUYOSHI (JP)
ICHIKAWA HIROYUKI (JP)
AKAMATSU SEIJI (JP)
SAITO FUMIO (JP)
TOMINAGA MICHIAKI (JP)
ADACHI MASAKAZU (JP)

Application Number:

PCT/JP1993/001144

Publication Date:

March 03, 1994

Filing Date:

August 12, 1993

Export Citation:

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Assignee:

OTSUKA PHARMA CO LTD (JP)
NAKAI SATORU (JP)
AIHARA KOUTOKU (JP)
TANAKA HIDEO (JP)
IBA HITOMI (JP)
KAWAI KAZUYOSHI (JP)
ICHIKAWA HIROYUKI (JP)
AKAMATSU SEIJI (JP)
SAITO FUMIO (JP)
TOMINAGA MICHIAKI (JP)
ADACHI MASAKAZU (JP)

International Classes:

C07D215/227; C07D215/38; C07D215/22; (IPC1-7): C07D215/22; A61K31/495

Foreign References:

JPS54128583A	1979-10-05
JPS5636452A	1981-04-09
JPS5742673A	1982-03-10
JPS59104378A	1984-06-16
JPS60248667A	1985-12-09
JPS6222767A	1987-01-30
JPS62135423A	1987-06-18
JPS5777676A	1982-05-15
JPS5883677A	1983-05-19
JPS5929667A	1984-02-16
JPS61267556A	1986-11-27
JPS63225357A	1988-09-20

Other References: