Title:
APOPTOTIC SIGNAL REGULATION KINASE INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/157857
Kind Code:
A1
Abstract:
Provided are an amide derivative inhibitor, a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, as well as a use thereof as an ASK1 inhibitor in the treatment of regressive neurological diseases, cardiovascular diseases, inflammation and autoimmune and metabolic diseases; each substituent in general formula (I) is the same as that defined in the description.
Inventors:
GAO PENG (CN)
TAN SONGLIANG (CN)
XIU WENHUA (CN)
ZHANG FUJUN (CN)
LIU LEI (CN)
BAO RUDI (CN)
TAN SONGLIANG (CN)
XIU WENHUA (CN)
ZHANG FUJUN (CN)
LIU LEI (CN)
BAO RUDI (CN)
Application Number:
PCT/CN2018/077873
Publication Date:
September 07, 2018
Filing Date:
March 02, 2018
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
C07D233/56; A61K31/437; A61K31/4439; A61P1/16; A61P3/00; C07D401/14; C07D403/14; C07D471/04
Domestic Patent References:
| WO2016025474A1 | 2016-02-18 |
Foreign References:
| CN107793400A | 2018-03-13 | |||
| CN102482257A | 2012-05-30 | |||
| CN104080771A | 2014-10-01 |
Other References:
LANIER, M. ET AL.: "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure", ACS MED. CHEM. LETT., vol. 8, no. 3, 8 February 2017 (2017-02-08), pages 316 - 320, XP055537904
LEE, J.H. ET AL.: "Discovery and Initial SAR of Pyrimidin-4-yl-1H-imidazole Derivatives with Antiproliferative Activity against Melanoma Cell Lines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 5, 21 January 2010 (2010-01-21), pages 1573 - 1577, XP026911307
LEE, J.H. ET AL.: "Discovery and Initial SAR of Pyrimidin-4-yl-1H-imidazole Derivatives with Antiproliferative Activity against Melanoma Cell Lines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, no. 5, 21 January 2010 (2010-01-21), pages 1573 - 1577, XP026911307
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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