Title:
APPARATUS FOR ANALYZING CANCER CELLS USING CELL SURFACE MICROSTRUCTURE ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2011/105847
Kind Code:
A2
Abstract:
The present invention relates to an apparatus for analyzing cancer cells using cell surface microstructure analysis, and more particularly, to an apparatus for analyzing cancer cells, comprising: an atomic force microscope (AFM) for observing the surface of a specimen cell; a first calculation unit for extracting a cell boundary from the image of the surface of the specimen cell observed by the AFM; and a second calculation unit for calculating a fractal dimension (FD) from the extracted cell boundary. The apparatus for analyzing cancer cells according to the present invention analyzes the fractal dimension for the microstructure of the cell boundary, and the microstructure of the surface of a disease cell, such as a tumor cell, has a unique FD value which is different from that of a normal cell. Particularly, a metastatic cancer cell tends to have a fractal dimension remarkably lower than that of a non-metastatic cancer cell. Thus, the apparatus of the present invention collects FD information on an ultra-low volume of tumor cells, and effectively uses the collected information in predicting and diagnosing various characteristics of tumor cells such as the progression of tumor cells, and whether tumor cells are malignant or benign. In addition, the apparatus of the present invention can measure, at a nanoscale level, the structure of surfaces of live cells, and therefore can be valuably used in the development of biological tools for the study of cells, that is, for the analysis of the ultra-microstructures of the surfaces of cells.
Inventors:
LEE, Kun Ho (5508Ho College of natural Sciences, Chosun University375 Seoseok-dong, Dong-gu, Gwangju 501-759, 501-759, KR)
이건호 (광주광역시 동구 서석동 375 조선대학교 자연과학대학 5508호, 501-759 Gwangju, 501-759, KR)
KANG, Chi Jung (Department of Physics, College of natural SciencesMyongji Univ.,San 38-2 Nam-dong, Cheoin-gu, Yongin-si, Gyeonggi-do 449-030, 449-030, KR)
강치중 (경기도 용인시 처인구 남동 산 38-2 명지대학교 자연과학대학 물리학과, 449-030 Gyeonggi-do, 449-030, KR)
이건호 (광주광역시 동구 서석동 375 조선대학교 자연과학대학 5508호, 501-759 Gwangju, 501-759, KR)
KANG, Chi Jung (Department of Physics, College of natural SciencesMyongji Univ.,San 38-2 Nam-dong, Cheoin-gu, Yongin-si, Gyeonggi-do 449-030, 449-030, KR)
강치중 (경기도 용인시 처인구 남동 산 38-2 명지대학교 자연과학대학 물리학과, 449-030 Gyeonggi-do, 449-030, KR)
Application Number:
KR2011/001325
Publication Date:
September 01, 2011
Filing Date:
February 25, 2011
Export Citation:
Assignee:
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY (Chosun University, 375 Seoseok-dong Dong-gu, Gwangju 501-759, 501-759, KR)
조선대학교 산학협력단 (광주광역시 동구 서석동 375 조선대학교 내, 501-759 Gwangju, 501-759, KR)
LEE, Kun Ho (5508Ho College of natural Sciences, Chosun University375 Seoseok-dong, Dong-gu, Gwangju 501-759, 501-759, KR)
이건호 (광주광역시 동구 서석동 375 조선대학교 자연과학대학 5508호, 501-759 Gwangju, 501-759, KR)
KANG, Chi Jung (Department of Physics, College of natural SciencesMyongji Univ.,San 38-2 Nam-dong, Cheoin-gu, Yongin-si, Gyeonggi-do 449-030, 449-030, KR)
조선대학교 산학협력단 (광주광역시 동구 서석동 375 조선대학교 내, 501-759 Gwangju, 501-759, KR)
LEE, Kun Ho (5508Ho College of natural Sciences, Chosun University375 Seoseok-dong, Dong-gu, Gwangju 501-759, 501-759, KR)
이건호 (광주광역시 동구 서석동 375 조선대학교 자연과학대학 5508호, 501-759 Gwangju, 501-759, KR)
KANG, Chi Jung (Department of Physics, College of natural SciencesMyongji Univ.,San 38-2 Nam-dong, Cheoin-gu, Yongin-si, Gyeonggi-do 449-030, 449-030, KR)
International Classes:
G01N33/483; C12N5/09; G01B5/28
Attorney, Agent or Firm:
LEE, Moon-Sup (Suite 301 Chungdong Building, 1659-2 Inhundong Gwanak-gu, Seoul 151-832, 151-832, KR)
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