Title:
APPARATUS AND METHOD FOR FABRICATING, SORTING, AND INTEGRATING MATERIALS WITH HOLOGRAPHIC OPTICAL TRAPS
Document Type and Number:
WIPO Patent Application WO2004014112
Kind Code:
A3
Abstract:
An apparatus and method for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials are disclosed. The apparatus and method involves the use of one or more diffractive optical elements which each receive a laser beam and form a plurality of laser beams. These laser beams are operated on by a telescope lens system and then an objective lens element to create an array of optical traps for manipulating, effecting interaction of , photochemically transforming and/or small dielectric particles or other materials. One object of the invention is to provide an improved method and system for using optical traps to incorporate foreign matter into living cells. Another object of the invention is to provide an improved method and system to sort optically nonabsorbing particles from optically absorbing particles. Yet another object ot the invention is to provide an improved method and system to implement the fabrication of heterogeneous structures using spatially resolved photochemistry.
Inventors:
GRIER DAVID G
DUFRESNE ERIC R
DUFRESNE ERIC R
Application Number:
PCT/US2003/023991
Publication Date:
October 07, 2004
Filing Date:
July 31, 2003
Export Citation:
Assignee:
UNIV CHICAGO (US)
International Classes:
G02B5/18; C12N13/00; C12N15/09; C12N15/87; C12N15/88; G02B5/32; G02B27/42; G21K1/00; H01H3/04; (IPC1-7): H05H3/04; G02B27/42; G02B21/32; G02B27/10; G21K1/06; C12N15/88
Domestic Patent References:
| WO1999039223A1 | 1999-08-05 |
Other References:
MUNCE N. R. ET AL: "Optical micromanipulation and analysis of single cells on a microchip platform", PROCEEDINGS OF SPIE-THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING: OPTICAL DIAGNOSTICS OF LIVING CELLS V, vol. 4622, 2002, pages 176 - 182, XP002276074
STEUBING R. W. ET AL: "LASER INDUCED CELL FUSION IN COMBINATION WITH OPTICAL TWEEZERS THE LASER CELL FUSION TRAP", CYTOMETRY, vol. 12, no. 6, 1991, pages 505 - 510, XP009028745, ISSN: 0196-4763
BERNS MICHAEL W: "Laser scissors and tweezers", SCIENTIFIC AMERICAN, vol. 278, no. 4, April 1998 (1998-04-01), pages 62 - 67, XP009028743, ISSN: 0036-8733
DUFRESNE E. R. ET AL.: "OPTICAL TWEEZER ARRAYS AND OPTICAL SUBSTRATES CREATED WITH DIFFRACTIVE OPTICS", REVIEW OF SCIENTIFIC INSTRUMENTS, vol. 69, no. 5, May 1998 (1998-05-01), pages 1974 - 1977, XP000833479, ISSN: 0034-6748
GRIER DAVID G: "A revolution in optical manipulation.", NATURE, vol. 424, no. 6950, 14 August 2003 (2003-08-14), pages 810 - 816, XP002276075, ISSN: 0028-0836 (ISSN print)
STEUBING R. W. ET AL: "LASER INDUCED CELL FUSION IN COMBINATION WITH OPTICAL TWEEZERS THE LASER CELL FUSION TRAP", CYTOMETRY, vol. 12, no. 6, 1991, pages 505 - 510, XP009028745, ISSN: 0196-4763
BERNS MICHAEL W: "Laser scissors and tweezers", SCIENTIFIC AMERICAN, vol. 278, no. 4, April 1998 (1998-04-01), pages 62 - 67, XP009028743, ISSN: 0036-8733
DUFRESNE E. R. ET AL.: "OPTICAL TWEEZER ARRAYS AND OPTICAL SUBSTRATES CREATED WITH DIFFRACTIVE OPTICS", REVIEW OF SCIENTIFIC INSTRUMENTS, vol. 69, no. 5, May 1998 (1998-05-01), pages 1974 - 1977, XP000833479, ISSN: 0034-6748
GRIER DAVID G: "A revolution in optical manipulation.", NATURE, vol. 424, no. 6950, 14 August 2003 (2003-08-14), pages 810 - 816, XP002276075, ISSN: 0028-0836 (ISSN print)
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