Title:
APPARATUS AND PROCESS FOR MONITORING MIGRATORY CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2006044066
Kind Code:
A3
Abstract:
An apparatus and process for monitoring migratory cell proliferation with restricted migration on a substrate includes providing a substrate, coating the substrate with extracellular matrix, plating cells suspended in cell culture media on extracellular matrix, and placing intersecting channels across the extracellular matrix components by removing the extracellular matrix components from the channels to isolate islands of the extracellular matrix components on the substrate. When the cells are immersed with a fluid, migration of the cells is confined to the isolated islands of the extracellular matrix components, permitting long-term observation of a migratory population.
Inventors:
RAVIN REA (US)
SULLIVAN JAMES V (US)
HOEPPNER DANIEL (US)
MUNNO DAVID W (US)
MCKAY RON (US)
SULLIVAN JAMES V (US)
HOEPPNER DANIEL (US)
MUNNO DAVID W (US)
MCKAY RON (US)
Application Number:
PCT/US2005/032657
Publication Date:
June 08, 2006
Filing Date:
September 14, 2005
Export Citation:
Assignee:
US HEALTH (US)
RAVIN REA (US)
SULLIVAN JAMES V (US)
HOEPPNER DANIEL (US)
MUNNO DAVID W (US)
MCKAY RON (US)
RAVIN REA (US)
SULLIVAN JAMES V (US)
HOEPPNER DANIEL (US)
MUNNO DAVID W (US)
MCKAY RON (US)
International Classes:
G01N33/543; B81C1/00; C12M1/34
Domestic Patent References:
| WO2001070389A2 | 2001-09-27 |
Foreign References:
| US6368838B1 | 2002-04-09 | |||
| US6133030A | 2000-10-17 |
Other References:
XIA, Y. ET AL.: "Unconventional Methods for Fabricating and Patterning Nanostructures", CHEM. REV., vol. 99, 1999, USA, pages 1823 - 1848, XP002373676
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