Title:
APPLICATION OF ADENOSINE OR ADENOSINE MONOPHOSPHATE IN PREPARATION OF ANTI-INFECTIVE DRUGS
Document Type and Number:
WIPO Patent Application WO/2023/115757
Kind Code:
A1
Abstract:
An application of adenosine or adenosine monophosphate in preparation of anti-infective drugs. Adenosine or adenosine monophosphate can significantly improve the sensitivity of clinical bacteria such as Escherichia coli, Aeromonas hydrophila, vibrio comprising vibrio alginolyticus and vibrio parahaemolyticus, streptococcus pyogenes, pseudomonas aeruginosa, Enterococcus Faecium, streptococcus iniae, Acinetobacter baumannii, and Klebsiella pneumoniae to antibiotics such as cefoperazone-sulbactam, ceftazidime, ceftriaxone sodium, cefoperazone, meropenem, imipenem, ciprofloxacin, ampenem, moxifloxacin, levofloxacin, gentamicin, amikacin, and kanamycin. Adenosine or adenosine monophosphate can be used in combination with an antibiotic as an anti-infective drug, kill bacteria under a low-concentration antibiotic condition, and reduce bacterial drug resistance.
Inventors:
LI HUI (CN)
PENG BO (CN)
PENG XUANXIAN (CN)
XIANG JUANJUAN (CN)
TAO JIANJUN (CN)
PENG BO (CN)
PENG XUANXIAN (CN)
XIANG JUANJUAN (CN)
TAO JIANJUN (CN)
Application Number:
PCT/CN2022/086177
Publication Date:
June 29, 2023
Filing Date:
April 11, 2022
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
A61K31/7076; A61K45/06; A61P31/04
Foreign References:
| CN114159456A | 2022-03-11 | |||
| US5872104A | 1999-02-16 | |||
| KR20180009167A | 2018-01-26 | |||
| CN103386131A | 2013-11-13 |
Other References:
KUSADA HIROYUKI, HANADA SATOSHI, KAMAGATA YOICHI, KIMURA NOBUTADA: "The effects of N-acylhomoserine lactones, β-lactam antibiotics and adenosine on biofilm formation in the multi-β-lactam antibiotic-resistant bacterium Acidovorax sp. strain MR-S7", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, vol. 118, no. 1, 1 July 2014 (2014-07-01), NL , pages 14 - 19, XP093073309, ISSN: 1389-1723, DOI: 10.1016/j.jbiosc.2013.12.012
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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