Title:
APPLICATION OF BACTEROIDES FRAGILIS CAPSULAR POLYSACCHARIDE A IN COMBINATION WITH PD-1 INHIBITOR IN PREPARATION OF PHARMACEUTICAL FOR TREATING SKIN TUMORS
Document Type and Number:
WIPO Patent Application WO/2023/134194
Kind Code:
A1
Abstract:
An application of bacteroides fragilis capsular polysaccharide A in combination with a PD-1 inhibitor in the preparation of a pharmaceutical for treating skin tumors; in particular, capsular polysaccharide A of bacteroides fragilis ZY-312 having preservation number CGMCC No. 10685 can achieve a synergistic effect with a PD-1 antibody, an immune factor can be regulated, a state of an immune cell can be improved, an anti-tumor immune response of an organism is enhanced, and the growth and proliferation rate of a skin tumor can be remarkably inhibited, such as a malignant melanoma and a squamous cell carcinoma; the capsular polysaccharide A is used as a main active ingredient, and same can be prepared into a biological agent such as a pharmaceutical formulation or a pharmaceutical composition.
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Inventors:
ZHENG LIJUN (CN)
YI XIAOMIN (CN)
CHANG XIUJUAN (CN)
LIANG DEBAO (CN)
YI XIAOMIN (CN)
CHANG XIUJUAN (CN)
LIANG DEBAO (CN)
Application Number:
PCT/CN2022/119439
Publication Date:
July 20, 2023
Filing Date:
September 16, 2022
Export Citation:
Assignee:
GUANGZHOU ZHIYI BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/715; A61K45/06; A61K39/395; A61P35/00
Foreign References:
| CN114404598A | 2022-04-29 | |||
| CN113730443A | 2021-12-03 | |||
| CN113234770A | 2021-08-10 | |||
| CN105434476A | 2016-03-30 | |||
| CN110025636A | 2019-07-19 |
Other References:
M. VETIZOU, J. M. PITT, R. DAILLERE, P. LEPAGE, N. WALDSCHMITT, C. FLAMENT, S. RUSAKIEWICZ, B. ROUTY, M. P. ROBERTI, C. P. M. DUON: "Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 350, no. 6264, 27 November 2015 (2015-11-27), US , pages 1079 - 1084, XP055691620, ISSN: 0036-8075, DOI: 10.1126/science.aad1329
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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