Title:
APPLICATION OF BACTEROIDES FRAGILIS AND PD-1 OR PD-L1 ANTIBODY DRUG COMBINATION IN TREATING GENITOURINARY SYSTEM CANCER
Document Type and Number:
WIPO Patent Application WO/2023/134208
Kind Code:
A1
Abstract:
Provided is an application of bacteroides fragilis and a PD-1 antibody and/or PD-L1 antibody drug combination in preventing and treating a genitourinary system tumor. A large number of experiments haven proven that bacteroides fragilis, and in particular bacteroides fragilis ZY-312 having preservation number CGMCC No. 10685, can improve a state of an immune cell, enhance the anti-tumor immune response of an organism, and effectively prevent and treat a genitourinary system tumor by means of regulating an immune factor.
Inventors:
WU JIAQI (CN)
WANG CONGFENG (CN)
NI SAI (CN)
CHEN JIA (CN)
WANG CONGFENG (CN)
NI SAI (CN)
CHEN JIA (CN)
Application Number:
PCT/CN2022/120026
Publication Date:
July 20, 2023
Filing Date:
September 20, 2022
Export Citation:
Assignee:
GUANGZHOU ZHIYI BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K39/395; A23C9/152; A23C9/16; A23C19/09; A23G9/36; A23L7/104; A23L33/10; A23L33/135; A61K35/741; A61P35/00
Foreign References:
| CN114425080A | 2022-05-03 | |||
| CN114344325A | 2022-04-15 | |||
| CN114469987A | 2022-05-13 | |||
| CN110267651A | 2019-09-20 | |||
| CN110496140A | 2019-11-26 | |||
| CN109528775A | 2019-03-29 | |||
| US20200384040A1 | 2020-12-10 | |||
| CN112587552A | 2021-04-02 |
Other References:
GUO, HENGZHAO: "A double-center, Random Controlled Clinical Study on BF839 Enhancing the Efficacy of PD-1 Antibody in the Treatment of Advanced Lung Cancer and Reducing Side Effects", WEDOCTOR, 200210811, CN, pages 1 - 7, XP009547894, Retrieved from the Internet [retrieved on 20230918]
M. VETIZOU, J. M. PITT, R. DAILLERE, P. LEPAGE, N. WALDSCHMITT, C. FLAMENT, S. RUSAKIEWICZ, B. ROUTY, M. P. ROBERTI, C. P. M. DUON: "Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 350, no. 6264, 27 November 2015 (2015-11-27), US , pages 1079 - 1084, XP055310374, ISSN: 0036-8075, DOI: 10.1126/science.aad1329
DAN HUIMIN, ZHOU YONGNING, GUAN QUANLIN: "Research Progress of Intestinal Microbiota and Immune Checkpoint Inhibitors", CANCER RESEARCH ON PREVENTION AND TREATMENT, MAGAZINE HOUSE OF CANCER RESEARCH ON PREVENTION AND TREATMENT, vol. 46, no. 11, 1 November 2019 (2019-11-01), pages 1026 - 1030, XP093078379, ISSN: 1000-8578, DOI: 10.3971/j.issn.1000-8578.2019.19.0311
LI YUN, ZHANG CHENG, XU YU-HANG, LI XIAO-YAN: "Research progress on impact of gut microbiota on cancer immunotherapy upon immune-checkpoint blockers", CHINESE JOURNAL OF IMMUNOLOGY, vol. 34, no. 2, 1 January 2018 (2018-01-01), pages 310 - 316, XP093079275, DOI: 10.3969/j.issn.1000-484X.2018.02.032
MAZMANIAN SARKIS K., LIU CUI HUA, TZIANABOS ARTHUR O., KASPER DENNIS L.: "An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System", CELL, ELSEVIER, AMSTERDAM NL, vol. 122, no. 1, 1 July 2005 (2005-07-01), Amsterdam NL , pages 107 - 118, XP093078382, ISSN: 0092-8674, DOI: 10.1016/j.cell.2005.05.007
ZHANG, JIJIE ET AL.: "Clinical Application of Bacteroides Fragilis (BF839) Fluid", CHINESE JOURNAL OF BIOLOGICALS, 8 February 1995 (1995-02-08), pages 63 - 65, XP055582450, DOI: 10.13200/j.cjb.1995.02.63.zhangjj.006
M. VETIZOU, J. M. PITT, R. DAILLERE, P. LEPAGE, N. WALDSCHMITT, C. FLAMENT, S. RUSAKIEWICZ, B. ROUTY, M. P. ROBERTI, C. P. M. DUON: "Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 350, no. 6264, 27 November 2015 (2015-11-27), US , pages 1079 - 1084, XP055310374, ISSN: 0036-8075, DOI: 10.1126/science.aad1329
DAN HUIMIN, ZHOU YONGNING, GUAN QUANLIN: "Research Progress of Intestinal Microbiota and Immune Checkpoint Inhibitors", CANCER RESEARCH ON PREVENTION AND TREATMENT, MAGAZINE HOUSE OF CANCER RESEARCH ON PREVENTION AND TREATMENT, vol. 46, no. 11, 1 November 2019 (2019-11-01), pages 1026 - 1030, XP093078379, ISSN: 1000-8578, DOI: 10.3971/j.issn.1000-8578.2019.19.0311
LI YUN, ZHANG CHENG, XU YU-HANG, LI XIAO-YAN: "Research progress on impact of gut microbiota on cancer immunotherapy upon immune-checkpoint blockers", CHINESE JOURNAL OF IMMUNOLOGY, vol. 34, no. 2, 1 January 2018 (2018-01-01), pages 310 - 316, XP093079275, DOI: 10.3969/j.issn.1000-484X.2018.02.032
MAZMANIAN SARKIS K., LIU CUI HUA, TZIANABOS ARTHUR O., KASPER DENNIS L.: "An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System", CELL, ELSEVIER, AMSTERDAM NL, vol. 122, no. 1, 1 July 2005 (2005-07-01), Amsterdam NL , pages 107 - 118, XP093078382, ISSN: 0092-8674, DOI: 10.1016/j.cell.2005.05.007
ZHANG, JIJIE ET AL.: "Clinical Application of Bacteroides Fragilis (BF839) Fluid", CHINESE JOURNAL OF BIOLOGICALS, 8 February 1995 (1995-02-08), pages 63 - 65, XP055582450, DOI: 10.13200/j.cjb.1995.02.63.zhangjj.006
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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