Title:
APPLICATION OF BAZ2B GENE AS TARGET IN SLOWING AGING
Document Type and Number:
WIPO Patent Application WO/2020/155977
Kind Code:
A1
Abstract:
Provided is an application of a BAZ2B gene as a target in slowing aging. It is disclosed that the BAZ2B gene plays an important regulatory role in occurrence and development of normal aging and age-related diseases, and the down-regulation thereof can significantly slow aging and improve memory decay, capacity degradation and the like in the aging process. The BAZ2B can be used as the research target of aging and age-related diseases for developing drugs of inhibiting or delaying aging, and used as a diagnostic and prognostic marker of aging and age-related diseases.
Inventors:
CAI SHIQING (CN)
YUAN JIE (CN)
CHANG SIYUAN (CN)
LIU ZHIYANG (CN)
YUAN JIE (CN)
CHANG SIYUAN (CN)
LIU ZHIYANG (CN)
Application Number:
PCT/CN2019/129018
Publication Date:
August 06, 2020
Filing Date:
December 27, 2019
Export Citation:
Assignee:
CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECHNOLOGY CHINESE ACAD OF SCIENCES (CN)
International Classes:
C12Q1/6883; A61K45/00; A61P25/28; A61P39/06; G01N33/68
Foreign References:
| CN105506065A | 2016-04-20 | |||
| EP2924125B1 | 2017-06-14 |
Other References:
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AMATO, A. ET AL.: "Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach", ACS CHEM. BIOL., vol. 13, 12 March 2018 (2018-03-12), pages 915 - 921, XP055729120
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DELGADO-MORALES, R.ESTELLER, M.: "Opening up the DNA methylome of dementia", MOL PSYCHIATR, vol. 22, 2017, pages 485 - 496
GREER, E.L.MAURES, T.J.HAUSWIRTH, A.G.GREEN, E.M.LEEMAN, D.S.MARO, G.S.HAN, S.BANKO, M.R.GOZANI, O.BRUNET, A.: "Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans", NATURE, vol. 466, 2010, pages 383 - 387
IMAI, S.GUARENTE, L.: "NAD+ and sirtuins in aging and disease", TRENDS CELL BIOL, vol. 24, 2014, pages 464 - 471, XP055321389, DOI: 10.1016/j.tcb.2014.04.002
JIN, C.LI, J.GREEN, C.D.YU, X.TANG, X.HAN, D.XIAN, B.WANG, D.HUANG, X.CAO, X. ET AL.: "Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway", CELL METAB, vol. 14, 2011, pages 161 - 172
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LU, T.PAN, Y.KAO, S.Y.LI, C.KOHANE, I.CHAN, J.YANKNER, B.A.: "Gene regulation and DNA damage in the ageing human brain", NATURE, vol. 429, 2004, pages 883 - 891
SATOH, A.IMAI, S.GUARENTE, L.: "The brain, sirtuins, and ageing", NAT REV NEUROSCI, vol. 18, 2017, pages 362 - 374
SEN, P.SHAH, P.P.NATIVIO, R.BERGER, S.L.: "Epigenetic Mechanisms of Longevity and Aging", CELL, vol. 166, 2016, pages 822 - 839, XP029682903, DOI: 10.1016/j.cell.2016.07.050
YEOMAN, M.SCUTT, G.FARAGHER, R.: "Insights into CNS ageing from animal models of senescence", NAT REV NEUROSCI, vol. 13, 2012, pages 435 - 445
MA JIAN, ZHOU JIE, LI XIAO LING, GONG JIA LEI, HE XIAN FENG, TANG KE, YANG JIAN BO, HU GENG XI, LI GUI YUAN: "Changes of Expression Profile Induced by NGX 6 Transfection in Nasopharyngeal Carcinoma Cells", ZHONGGUO SHENGWU HUAXUE YU FENZI SHENGWU XUEBAO - CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 18, no. 4, 1 August 2002 (2002-08-01), CN, pages 416 - 422, XP009529930, ISSN: 1007-7626, DOI: 10.13865/j.cnki.cjbmb.2002.04.005
CHEN, P. ET AL: "Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 4, 23 March 2015 (2015-03-23), pages 1410 - 1424, XP055729122
AMATO, A. ET AL.: "Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach", ACS CHEM. BIOL., vol. 13, 12 March 2018 (2018-03-12), pages 915 - 921, XP055729120
"GenBank", Database accession no. NM 001001182
J. SAMBROOK: "Molecular Cloning: A Laboratory Manual", 2002, SCIENCE PRESS,
AKBARIAN, S.BEERI, M.S.HAROUTUNIAN, V.: "Epigenetic determinants of healthy and diseased brain aging and cognition", JAMA NEUROL, vol. 70, 2013, pages 711 - 718
BISHOP, N.A.LU, T.YANKNER, B.A.: "Neural mechanisms of ageing and cognitive decline", NATURE, vol. 464, 2010, pages 529 - 535
DANG, W.SUTPHIN, G.L.DORSEY, J.A.OTTE, G.L.CAO, K.PERRY, R.M.WANAT, J.J.SAVIOLAKI, D.MURAKAMI, C.J.TSUCHIYAMA, S. ET AL.: "Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response", CELL METAB, vol. 19, 2014, pages 952 - 966
DELGADO-MORALES, R.ESTELLER, M.: "Opening up the DNA methylome of dementia", MOL PSYCHIATR, vol. 22, 2017, pages 485 - 496
GREER, E.L.MAURES, T.J.HAUSWIRTH, A.G.GREEN, E.M.LEEMAN, D.S.MARO, G.S.HAN, S.BANKO, M.R.GOZANI, O.BRUNET, A.: "Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans", NATURE, vol. 466, 2010, pages 383 - 387
IMAI, S.GUARENTE, L.: "NAD+ and sirtuins in aging and disease", TRENDS CELL BIOL, vol. 24, 2014, pages 464 - 471, XP055321389, DOI: 10.1016/j.tcb.2014.04.002
JIN, C.LI, J.GREEN, C.D.YU, X.TANG, X.HAN, D.XIAN, B.WANG, D.HUANG, X.CAO, X. ET AL.: "Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway", CELL METAB, vol. 14, 2011, pages 161 - 172
LOPEZ-OTIN, C.BLASCO, M.A.PARTRIDGE, L.SERRANO, M.KROEMER, G.: "The hallmarks of aging", CELL, vol. 153, 2013, pages 1194 - 1217, XP028563547, DOI: 10.1016/j.cell.2013.05.039
LU, T.PAN, Y.KAO, S.Y.LI, C.KOHANE, I.CHAN, J.YANKNER, B.A.: "Gene regulation and DNA damage in the ageing human brain", NATURE, vol. 429, 2004, pages 883 - 891
SATOH, A.IMAI, S.GUARENTE, L.: "The brain, sirtuins, and ageing", NAT REV NEUROSCI, vol. 18, 2017, pages 362 - 374
SEN, P.SHAH, P.P.NATIVIO, R.BERGER, S.L.: "Epigenetic Mechanisms of Longevity and Aging", CELL, vol. 166, 2016, pages 822 - 839, XP029682903, DOI: 10.1016/j.cell.2016.07.050
YEOMAN, M.SCUTT, G.FARAGHER, R.: "Insights into CNS ageing from animal models of senescence", NAT REV NEUROSCI, vol. 13, 2012, pages 435 - 445
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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