Title:
APPLICATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR PRECURSOR PROTEIN AS TARGET SPOT FOR TREATING AFFECTIVE DISORDERS
Document Type and Number:
WIPO Patent Application WO/2017/028782
Kind Code:
A1
Abstract:
Application of a binding molecule having an activity neutralizing or inhibiting function on brain-derived neurotrophic factor precursor protein (proBDNF) or a signal transfer molecule thereof, or a binding molecule having an activity stimulating or promoting function on BDNF or a signal transfer molecule thereof, in preparing medicine for preventing, relieving or treating affective disorders. It is found for the first time that proBDNF is an important target spot for treating affective disorders comprising depression disorder, and a binding molecule of the proBDNF is specifically combined, so as to have a significant effect of preventing, relieving or treating affective disorders.
Inventors:
ZHOU XINFU (CN)
Application Number:
PCT/CN2016/095628
Publication Date:
February 23, 2017
Filing Date:
August 17, 2016
Export Citation:
Assignee:
FUJIAN TIANTAI MEDICAL TECH CO LTD (CN)
International Classes:
C12N15/63; A61K39/395; C07K16/22
Domestic Patent References:
| WO2014144972A1 | 2014-09-18 |
Foreign References:
| CN103087997A | 2013-05-08 | |||
| CN101674819A | 2010-03-17 | |||
| CN104774264A | 2015-07-15 |
Other References:
SHIRAYAMA,Y. ET AL.: "Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression.", THE JOURNAL OF NEUROSCIENCE., vol. 22, no. 8, 15 April 2002 (2002-04-15), pages 3251 - 3261, XP001107166
ZHANG, J. C. ET AL.: "Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation.", INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY., 26 January 2015 (2015-01-26), pages 1 - 12, XP055369224
ZHOU, L. ET AL.: "Upregulation of blood proBDNF and its receptors in major depression", JOURNAL OF AFFECTIVE DISORDERS, vol. 150, 26 March 2013 (2013-03-26), pages 776 - 784, XP055369225
MARTINOWICH, K. ET AL.: "New insights into BDNF function in depression and anxiety.", NATURE NEUROSCIENCE., vol. 10, no. 9, 30 September 2007 (2007-09-30), pages 2882 - 2892, XP055346392
BAI, Y. Y. ET AL.: "ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress.", NEUROPSYCHOPHARMACOLOGY., vol. 41, 13 July 2016 (2016-07-13), pages 2882 - 2892, XP055369226
ZHANG, J. C. ET AL.: "Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation.", INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY., 26 January 2015 (2015-01-26), pages 1 - 12, XP055369224
ZHOU, L. ET AL.: "Upregulation of blood proBDNF and its receptors in major depression", JOURNAL OF AFFECTIVE DISORDERS, vol. 150, 26 March 2013 (2013-03-26), pages 776 - 784, XP055369225
MARTINOWICH, K. ET AL.: "New insights into BDNF function in depression and anxiety.", NATURE NEUROSCIENCE., vol. 10, no. 9, 30 September 2007 (2007-09-30), pages 2882 - 2892, XP055346392
BAI, Y. Y. ET AL.: "ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress.", NEUROPSYCHOPHARMACOLOGY., vol. 41, 13 July 2016 (2016-07-13), pages 2882 - 2892, XP055369226
Attorney, Agent or Firm:
CHINA SINDA INTELLECTUAL PROPERTY LTD. (CN)
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