Title:
APPLICATION OF β-CASEIN A2 AND COMPOSITION THEREOF IN PROMOTING PROLIFERATION OF BIFIDOBACTERIUM
Document Type and Number:
WIPO Patent Application WO/2021/003741
Kind Code:
A1
Abstract:
The application of β-casein A2 and composition thereof in promoting the proliferation of bifidobacterium. Compared with ordinary milk, milk containing β-casein A2 may significantly reduce the proportion of abdominal distension and borborygmus and increase the frequency of defecation, and may change stool characteristics. In addition, the milk containing β-casein A2 may significantly increase the relative abundance of bifidobacterium in intestinal bacteria.
Inventors:
CHEN LIJUN (CN)
LIU BIN (CN)
ZHAO JUNYING (CN)
JIANG TIEMIN (CN)
ZHOU WEIMING (CN)
LI JIANTAO (CN)
LIU YANPIN (CN)
QIAO WEICANG (CN)
LIU BIN (CN)
ZHAO JUNYING (CN)
JIANG TIEMIN (CN)
ZHOU WEIMING (CN)
LI JIANTAO (CN)
LIU YANPIN (CN)
QIAO WEICANG (CN)
Application Number:
PCT/CN2019/095620
Publication Date:
January 14, 2021
Filing Date:
July 11, 2019
Export Citation:
Assignee:
BEIJING SANYUAN FOODS CO LTD (CN)
International Classes:
A23C9/00; A61K35/20; A61P1/00
Foreign References:
| CN105407971A | 2016-03-16 | |||
| CN105431156A | 2016-03-23 | |||
| CN103315063A | 2013-09-25 | |||
| CN103636798A | 2014-03-19 |
Other References:
SUN JIANQIN, XU LEIMING, XIA LU, GREGORY W. YELLAND, JIAYI NI, ANDREW J. CLARKE: "Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows’ milk", NUTRITION JOURNAL, vol. 30, no. 1, 1 December 2015 (2015-12-01), pages 1854, XP055336964, DOI: 10.1186/s12937-016-0147-z
HE MEI, SUN JIANQIN, JIANG ZHUO QIN, YANG YUE XIN: "Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study", NUTRITION JOURNAL, vol. 16, no. 1, 1 December 2017 (2017-12-01), XP055773568, DOI: 10.1186/s12937-017-0275-0
STACEY J. BELL, GREGORY T. GROCHOSKI, ANDREW J. CLARKE: "Health Implications of Milk Containing β-Casein with the A 2 Genetic Variant", CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, TAYLOR & FRANCIS, USA, vol. 46, no. 1, 1 January 2006 (2006-01-01), USA, pages 93 - 100, XP055320269, ISSN: 1040-8398, DOI: 10.1080/10408390591001144
LIANG JIE; GENG XIAOHUI; LIU YANPING; YIN CHENYIN: "Progress of Polymorphism of β-casein in Milk and Its Relationship with Human Health", JOURNAL OF DAIRY SCIENCE AND TECHNOLOGY, vol. 42, no. 2, 1 March 2019 (2019-03-01), pages 45 - 49, XP009525493
HE MEI, SUN JIANQIN, JIANG ZHUO QIN, YANG YUE XIN: "Effects of cow’s milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study", NUTRITION JOURNAL, vol. 16, no. 1, 1 December 2017 (2017-12-01), XP055773568, DOI: 10.1186/s12937-017-0275-0
STACEY J. BELL, GREGORY T. GROCHOSKI, ANDREW J. CLARKE: "Health Implications of Milk Containing β-Casein with the A 2 Genetic Variant", CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, TAYLOR & FRANCIS, USA, vol. 46, no. 1, 1 January 2006 (2006-01-01), USA, pages 93 - 100, XP055320269, ISSN: 1040-8398, DOI: 10.1080/10408390591001144
LIANG JIE; GENG XIAOHUI; LIU YANPING; YIN CHENYIN: "Progress of Polymorphism of β-casein in Milk and Its Relationship with Human Health", JOURNAL OF DAIRY SCIENCE AND TECHNOLOGY, vol. 42, no. 2, 1 March 2019 (2019-03-01), pages 45 - 49, XP009525493
Attorney, Agent or Firm:
BEIJING YUEHE INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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