Title:
APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT, AND RELATED PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2019/184991
Kind Code:
A1
Abstract:
The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and the entry thereof into a target cell by using the extracted compounds or multiple combinations, and promoting the entry of the nucleic acid into a target site in an object body having such a need. The traditional Chinese medicine is selected from traditional Chinese medicine decoction pieces derived from Rhodiola rosea, Herba Taraxaci, Herba andrographitis, and Flos Lonicerae. The nucleic acid is used for treating diseases, such as heart, spleen, kidney, stomach, lung and/or bowel diseases.
Inventors:
JIANG CHENGYU (CN)
LI XIAOYUN (CN)
DU JIANCHAO (CN)
LIANG ZHU (CN)
WANG ZHIQING (CN)
WANG CHENXUAN (CN)
LI XIAOYUN (CN)
DU JIANCHAO (CN)
LIANG ZHU (CN)
WANG ZHIQING (CN)
WANG CHENXUAN (CN)
Application Number:
PCT/CN2019/080175
Publication Date:
October 03, 2019
Filing Date:
March 28, 2019
Export Citation:
Assignee:
INST BASIC MEDICAL SCIENCES CAMS (CN)
International Classes:
C07C219/00; A61K48/00; C07C229/00; C07C233/00; C07F9/09
Domestic Patent References:
| WO2008103276A2 | 2008-08-28 | |||
| WO2008074487A2 | 2008-06-26 | |||
| WO2016145031A1 | 2016-09-15 | |||
| WO2009129387A2 | 2009-10-22 | |||
| WO2009129385A1 | 2009-10-22 | |||
| WO2009129395A1 | 2009-10-22 | |||
| WO2018177383A1 | 2018-10-04 | |||
| WO2006074546A1 | 2006-07-20 |
Foreign References:
| JP2013245190A | 2013-12-09 | |||
| US20070293449A1 | 2007-12-20 | |||
| CN101842347A | 2010-09-22 | |||
| CN2018081155W | 2018-03-29 |
Other References:
CHILLEMI, ROSA ET AL.: "Oligonucleotides Conjugated to Natural Lipids: Synthesis of Phosphatidyl-Anchored Antisense Oligonucleotides", BIOCONJUGATE CHEMISTRY, vol. 24, no. 4, 1 March 2013 (2013-03-01), pages 648 - 657, XP055132684
"Real-time quantification of microRNAs by stem-loop RT-PCR", NUCLEIC ACIDS RES, vol. 33, no. 20, 27 November 2005 (2005-11-27), pages e179
See also references of EP 3778556A4
"Real-time quantification of microRNAs by stem-loop RT-PCR", NUCLEIC ACIDS RES, vol. 33, no. 20, 27 November 2005 (2005-11-27), pages e179
See also references of EP 3778556A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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