Title:
APPLICATION OF THE CRYSTAL STRUCTURE OF NUSA IN DRUG DISCOVERY
Document Type and Number:
WIPO Patent Application WO2003031986
Kind Code:
A3
Abstract:
The present invention relates to the structure and interactions of NusA, which is a component of the rrn anti-termination complex. Methods and means are provided for obtaining compounds which modulate the activity of NusA and thus modulate anti-termination. These compounds are useful in a therapeutic context.
Inventors:
ARNVIG KRISTINE (GB)
GOPAL BALASUBRAMANIAN (US)
DODSON GUY (GB)
COLSTON MICHAEL J DI
COX ROBERT A (GB)
GOPAL BALASUBRAMANIAN (US)
DODSON GUY (GB)
COLSTON MICHAEL J DI
COX ROBERT A (GB)
Application Number:
PCT/GB2002/004507
Publication Date:
April 01, 2004
Filing Date:
October 04, 2002
Export Citation:
Assignee:
MEDICAL RES COUNCIL (GB)
ARNVIG KRISTINE (GB)
GOPAL BALASUBRAMANIAN (US)
DODSON GUY (GB)
COX ROBERT A (GB)
COLSTON KAY HF (GB)
ARNVIG KRISTINE (GB)
GOPAL BALASUBRAMANIAN (US)
DODSON GUY (GB)
COX ROBERT A (GB)
COLSTON KAY HF (GB)
International Classes:
G16B15/30; G01N33/566; G01N33/68; (IPC1-7): C12Q1/18; G06F19/00; G01N33/569
Foreign References:
| US6225076B1 | 2001-05-01 | |||
| US6156526A | 2000-12-05 |
Other References:
GOPAL B ET AL: "Crystallization and preliminary X-ray diffraction studies on the N-utilizing substance A (NusA) from Mycobacterium tuberculosis", ACTA CRYSTALLOGRAPHICA SECTION D BIOLOGICAL CRYSTALLOGRAPHY, vol. 57, no. 8, August 2001 (2001-08-01), &, pages 1187 - 1188, XP008027024, ISSN: 0907-4449
WORBS MICHAEL ET AL: "An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA", MOLECULAR CELL, vol. 7, no. 6, June 2001 (2001-06-01), &, pages 1177 - 1189, XP002268749, ISSN: 1097-2765
GOPAL B ET AL: "The crystal structure of NusB from Mycobacterium tuberculosis", NATURE STRUCTURAL BIOLOGY, vol. 7, no. 6, June 2000 (2000-06-01), &, pages 475 - 478, XP002268750, ISSN: 1072-8368
WORBS MICHAEL ET AL: "An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA", MOLECULAR CELL, vol. 7, no. 6, June 2001 (2001-06-01), &, pages 1177 - 1189, XP002268749, ISSN: 1097-2765
GOPAL B ET AL: "The crystal structure of NusB from Mycobacterium tuberculosis", NATURE STRUCTURAL BIOLOGY, vol. 7, no. 6, June 2000 (2000-06-01), &, pages 475 - 478, XP002268750, ISSN: 1072-8368
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